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Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Zang J, et al. Among authors: dustin cm. J Med Chem. 2023 Nov 9;66(21):14963-15005. doi: 10.1021/acs.jmedchem.3c01548. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857466
Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence.
Li Y, Kračun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ. Li Y, et al. Among authors: dustin cm. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2015666118. doi: 10.1073/pnas.2015666118. Proc Natl Acad Sci U S A. 2021. PMID: 34654740 Free PMC article.
Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
Schiffers C, Lundblad LKA, Hristova M, Habibovic A, Dustin CM, Daphtary N, Aliyeva M, Seward DJ, Janssen-Heininger YMW, Wouters EFM, Reynaert NL, van der Vliet A. Schiffers C, et al. Among authors: dustin cm. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L144-L158. doi: 10.1152/ajplung.00021.2021. Epub 2021 May 5. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33951398 Free PMC article.
Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN.
Veith C, Hristova M, Danyal K, Habibovic A, Dustin CM, McDonough JE, Vanaudenaerde BM, Kreuter M, Schneider MA, Kahn N, van Schooten FJ, Boots AW, van der Vliet A. Veith C, et al. Among authors: dustin cm. Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L356-L367. doi: 10.1152/ajplung.00444.2019. Epub 2020 Dec 16. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33325804 Free PMC article.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Schiffers C, van de Wetering C, Bauer RA, Habibovic A, Hristova M, Dustin CM, Lambrichts S, Vacek PM, Wouters EF, Reynaert NL, van der Vliet A. Schiffers C, et al. Among authors: dustin cm. JCI Insight. 2021 Jan 25;6(2):e142189. doi: 10.1172/jci.insight.142189. JCI Insight. 2021. PMID: 33301419 Free PMC article.
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