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CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
Gallo D, Young JTF, Fourtounis J, Martino G, Álvarez-Quilón A, Bernier C, Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugère-Desjardins C, Goullet de Rugy T, Leclaire ME, Liu B, Bhaskaran V, Mamane Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkáč J, Yin SY, Morris SJ, Zinda M, Marshall CG, Durocher D. Gallo D, et al. Among authors: durocher d. Nature. 2022 Apr;604(7907):749-756. doi: 10.1038/s41586-022-04638-9. Epub 2022 Apr 20. Nature. 2022. PMID: 35444283 Free PMC article.
Telomere protection: an act of God.
Szilard RK, Durocher D. Szilard RK, et al. Among authors: durocher d. Curr Biol. 2006 Jul 25;16(14):R544-6. doi: 10.1016/j.cub.2006.06.037. Curr Biol. 2006. PMID: 16860732 Free article.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. O'Donnell L, et al. Among authors: durocher d. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 Nov 4. Mol Cell. 2010. PMID: 21055983 Free PMC article.
The ubiquitous role of ubiquitin in the DNA damage response.
Al-Hakim A, Escribano-Diaz C, Landry MC, O'Donnell L, Panier S, Szilard RK, Durocher D. Al-Hakim A, et al. Among authors: durocher d. DNA Repair (Amst). 2010 Dec 10;9(12):1229-40. doi: 10.1016/j.dnarep.2010.09.011. Epub 2010 Nov 4. DNA Repair (Amst). 2010. PMID: 21056014 Free PMC article. Review.
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D. Juang YC, et al. Among authors: durocher d. Mol Cell. 2012 Feb 10;45(3):384-97. doi: 10.1016/j.molcel.2012.01.011. Mol Cell. 2012. PMID: 22325355 Free PMC article.
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F. Wan LC, et al. Among authors: durocher d. Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25. Nucleic Acids Res. 2013. PMID: 23620299 Free PMC article.
133 results