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Control of homologous recombination by the HROB-MCM8-MCM9 pathway.
Hustedt N, Saito Y, Zimmermann M, Álvarez-Quilón A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D. Hustedt N, et al. Among authors: durocher d. Genes Dev. 2019 Oct 1;33(19-20):1397-1415. doi: 10.1101/gad.329508.119. Epub 2019 Aug 29. Genes Dev. 2019. PMID: 31467087 Free PMC article.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. O'Donnell L, et al. Among authors: durocher d. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 Nov 4. Mol Cell. 2010. PMID: 21055983 Free PMC article.
A mechanism for the suppression of homologous recombination in G1 cells.
Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D. Orthwein A, et al. Among authors: durocher d. Nature. 2015 Dec 17;528(7582):422-6. doi: 10.1038/nature16142. Epub 2015 Dec 9. Nature. 2015. PMID: 26649820 Free PMC article.
The control of DNA repair by the cell cycle.
Hustedt N, Durocher D. Hustedt N, et al. Among authors: durocher d. Nat Cell Biol. 2016 Dec 23;19(1):1-9. doi: 10.1038/ncb3452. Nat Cell Biol. 2016. PMID: 28008184 Review.
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. Leung JW, et al. Among authors: durocher d. Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27. Genes Dev. 2017. PMID: 28242625 Free PMC article.
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.
Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J. Hart T, et al. Among authors: durocher d. G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277. G3 (Bethesda). 2017. PMID: 28655737 Free PMC article.
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. Canny MD, et al. Among authors: durocher d. Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27. Nat Biotechnol. 2018. PMID: 29176614 Free PMC article.
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D. Zimmermann M, et al. Among authors: durocher d. Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4. Nature. 2018. PMID: 29973717 Free PMC article.
133 results