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Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt R, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, van Beusekom HMM, Ghanbari M, Hoeijmakers JHJ, Sedlacek R, Touyz RM, Montezano AC, van der Pluijm I, Danser AHJ, Haanes KA, Roks AJM. Bautista-Niño PK, et al. Among authors: durik m. Clin Sci (Lond). 2020 Apr 17;134(7):727-746. doi: 10.1042/CS20190124. Clin Sci (Lond). 2020. PMID: 32202295 Free article.
Red wine extract protects against oxidative-stress-induced endothelial senescence.
Botden IP, Oeseburg H, Durik M, Leijten FP, Van Vark-Van Der Zee LC, Musterd-Bhaggoe UM, Garrelds IM, Seynhaeve AL, Langendonk JG, Sijbrands EJ, Danser AH, Roks AJ. Botden IP, et al. Among authors: durik m. Clin Sci (Lond). 2012 Oct;123(8):499-507. doi: 10.1042/CS20110679. Clin Sci (Lond). 2012. PMID: 22563892
Nucleotide excision DNA repair is associated with age-related vascular dysfunction.
Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ. Durik M, et al. Circulation. 2012 Jul 24;126(4):468-78. doi: 10.1161/CIRCULATIONAHA.112.104380. Epub 2012 Jun 15. Circulation. 2012. PMID: 22705887 Free PMC article.
Phosphodiesterase 1 regulation is a key mechanism in vascular aging.
Bautista Niño PK, Durik M, Danser AH, de Vries R, Musterd-Bhaggoe UM, Meima ME, Kavousi M, Ghanbari M, Hoeijmakers JH, O'Donnell CJ, Franceschini N, Janssen GM, De Mey JG, Liu Y, Shanahan CM, Franco OH, Dehghan A, Roks AJ. Bautista Niño PK, et al. Among authors: durik m. Clin Sci (Lond). 2015 Dec;129(12):1061-75. doi: 10.1042/CS20140753. Epub 2015 Jun 25. Clin Sci (Lond). 2015. PMID: 26464516
Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/- mice.
Wu H, van Thiel BS, Bautista-Niño PK, Reiling E, Durik M, Leijten FPJ, Ridwan Y, Brandt RMC, van Steeg H, Dollé MET, Vermeij WP, Hoeijmakers JHJ, Essers J, van der Pluijm I, Danser AHJ, Roks AJM. Wu H, et al. Among authors: durik m. Clin Sci (Lond). 2017 Jul 13;131(15):1941-1953. doi: 10.1042/CS20170026. Print 2017 Aug 1. Clin Sci (Lond). 2017. PMID: 28620011
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Among authors: durik m. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.
19 results