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Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG. Vann KR, et al. Among authors: durden dl. Structure. 2022 Sep 1;30(9):1224-1232.e5. doi: 10.1016/j.str.2022.05.020. Epub 2022 Jun 17. Structure. 2022. PMID: 35716662 Free PMC article.
PI3K-α/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron.
Acharya A, Pathania AS, Pandey K, Thurman M, Vann KR, Kutateladze TG, Challagundala KB, Durden DL, Byrareddy SN. Acharya A, et al. Among authors: durden dl. Clin Transl Med. 2022 Apr;12(4):e806. doi: 10.1002/ctm2.806. Clin Transl Med. 2022. PMID: 35390226 Free PMC article. No abstract available.
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity.
Burgoyne AM, Vann KR, Joshi S, Morales GA, Vega FM, Singh A, Pal D, Merati AB, Kutateladze TG, Durden DL. Burgoyne AM, et al. Among authors: durden dl. Cell Discov. 2020 Jul 28;6(1):49. doi: 10.1038/s41421-020-0181-z. eCollection 2020. Cell Discov. 2020. PMID: 32793389 Free PMC article. No abstract available.
[No title available]
[No authors listed] [No authors listed] PMID: 34315865
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges.
Pathania AS, Prathipati P, Abdul BA, Chava S, Katta SS, Gupta SC, Gangula PR, Pandey MK, Durden DL, Byrareddy SN, Challagundla KB. Pathania AS, et al. Among authors: durden dl. Theranostics. 2021 Jan 1;11(2):731-753. doi: 10.7150/thno.51471. eCollection 2021. Theranostics. 2021. PMID: 33391502 Free PMC article. Review.
96 results