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The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis.
Flores-Costa R, Alcaraz-Quiles J, Titos E, López-Vicario C, Casulleras M, Duran-Güell M, Rius B, Diaz A, Hall K, Shea C, Sarno R, Currie M, Masferrer JL, Clària J. Flores-Costa R, et al. Br J Pharmacol. 2018 Mar;175(6):953-967. doi: 10.1111/bph.14137. Epub 2018 Jan 31. Br J Pharmacol. 2018. PMID: 29281143 Free PMC article.
Leukocytes from obese individuals exhibit an impaired SPM signature.
López-Vicario C, Titos E, Walker ME, Alcaraz-Quiles J, Casulleras M, Durán-Güell M, Flores-Costa R, Pérez-Romero N, Forné M, Dalli J, Clària J. López-Vicario C, et al. FASEB J. 2019 Jun;33(6):7072-7083. doi: 10.1096/fj.201802587R. Epub 2019 Mar 6. FASEB J. 2019. PMID: 30840838 Free article.
Proresolving lipid mediators and liver disease.
Clària J, Flores-Costa R, Duran-Güell M, López-Vicario C. Clària J, et al. Among authors: duran guell m. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov;1866(11):159023. doi: 10.1016/j.bbalip.2021.159023. Epub 2021 Aug 2. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34352389 Free article. Review.
Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals.
López-Vicario C, Rius B, Alcaraz-Quiles J, González-Périz A, Martínez-Puchol AI, Casulleras M, Duran-Güell M, Ibarzabal A, Corcelles R, Laguna-Fernández A, Back M, Titos E, Clària J. López-Vicario C, et al. Sci Rep. 2017 Nov 16;7(1):15724. doi: 10.1038/s41598-017-15951-z. Sci Rep. 2017. PMID: 29146976 Free PMC article.
Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit.
Flores-Costa R, Duran-Güell M, Casulleras M, López-Vicario C, Alcaraz-Quiles J, Diaz A, Lozano JJ, Titos E, Hall K, Sarno R, Masferrer JL, Clària J. Flores-Costa R, et al. Among authors: duran guell m. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28263-28274. doi: 10.1073/pnas.2000466117. Epub 2020 Oct 26. Proc Natl Acad Sci U S A. 2020. PMID: 33106416 Free PMC article.
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease.
López-Vicario C, Sebastián D, Casulleras M, Duran-Güell M, Flores-Costa R, Aguilar F, Lozano JJ, Zhang IW, Titos E, Kang JX, Zorzano A, Arita M, Clària J. López-Vicario C, et al. Among authors: duran guell m. Hepatology. 2023 Apr 1;77(4):1303-1318. doi: 10.1002/hep.32647. Epub 2022 Jul 15. Hepatology. 2023. PMID: 35788956 Free article.
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