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The tomato cytochrome P450 CYP712G1 catalyses the double oxidation of orobanchol en route to the rhizosphere signalling strigolactone, solanacol.
Wang Y, Durairaj J, Suárez Duran HG, van Velzen R, Flokova K, Liao CY, Chojnacka A, MacFarlane S, Schranz ME, Medema MH, van Dijk ADJ, Dong L, Bouwmeester HJ. Wang Y, et al. Among authors: durairaj j. New Phytol. 2022 Sep;235(5):1884-1899. doi: 10.1111/nph.18272. Epub 2022 Jun 18. New Phytol. 2022. PMID: 35612785 Free PMC article.
An analysis of characterized plant sesquiterpene synthases.
Durairaj J, Di Girolamo A, Bouwmeester HJ, de Ridder D, Beekwilder J, van Dijk AD. Durairaj J, et al. Phytochemistry. 2019 Feb;158:157-165. doi: 10.1016/j.phytochem.2018.10.020. Epub 2018 Nov 13. Phytochemistry. 2019. PMID: 30446165
The santalene synthase from Cinnamomum camphora: Reconstruction of a sesquiterpene synthase from a monoterpene synthase.
Di Girolamo A, Durairaj J, van Houwelingen A, Verstappen F, Bosch D, Cankar K, Bouwmeester H, de Ridder D, van Dijk ADJ, Beekwilder J. Di Girolamo A, et al. Among authors: durairaj j. Arch Biochem Biophys. 2020 Nov 30;695:108647. doi: 10.1016/j.abb.2020.108647. Epub 2020 Oct 26. Arch Biochem Biophys. 2020. PMID: 33121934 Free article.
Maize resistance to witchweed through changes in strigolactone biosynthesis.
Li C, Dong L, Durairaj J, Guan JC, Yoshimura M, Quinodoz P, Horber R, Gaus K, Li J, Setotaw YB, Qi J, De Groote H, Wang Y, Thiombiano B, Floková K, Walmsley A, Charnikhova TV, Chojnacka A, Correia de Lemos S, Ding Y, Skibbe D, Hermann K, Screpanti C, De Mesmaeker A, Schmelz EA, Menkir A, Medema M, Van Dijk ADJ, Wu J, Koch KE, Bouwmeester HJ. Li C, et al. Among authors: durairaj j. Science. 2023 Jan 6;379(6627):94-99. doi: 10.1126/science.abq4775. Epub 2023 Jan 5. Science. 2023. PMID: 36603079
Beyond sequence: Structure-based machine learning.
Durairaj J, de Ridder D, van Dijk ADJ. Durairaj J, et al. Comput Struct Biotechnol J. 2022 Dec 29;21:630-643. doi: 10.1016/j.csbj.2022.12.039. eCollection 2023. Comput Struct Biotechnol J. 2022. PMID: 36659927 Free PMC article. Review.
Artificial intelligence for natural product drug discovery.
Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Mullowney MW, et al. Among authors: durairaj j. Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11. Nat Rev Drug Discov. 2023. PMID: 37697042 Review.
A structural biology community assessment of AlphaFold2 applications.
Akdel M, Pires DEV, Pardo EP, Jänes J, Zalevsky AO, Mészáros B, Bryant P, Good LL, Laskowski RA, Pozzati G, Shenoy A, Zhu W, Kundrotas P, Serra VR, Rodrigues CHM, Dunham AS, Burke D, Borkakoti N, Velankar S, Frost A, Basquin J, Lindorff-Larsen K, Bateman A, Kajava AV, Valencia A, Ovchinnikov S, Durairaj J, Ascher DB, Thornton JM, Davey NE, Stein A, Elofsson A, Croll TI, Beltrao P. Akdel M, et al. Among authors: durairaj j. Nat Struct Mol Biol. 2022 Nov;29(11):1056-1067. doi: 10.1038/s41594-022-00849-w. Epub 2022 Nov 7. Nat Struct Mol Biol. 2022. PMID: 36344848 Free PMC article.
40 results