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Metformin targets gastric cancer stem cells.
Courtois S, Durán RV, Giraud J, Sifré E, Izotte J, Mégraud F, Lehours P, Varon C, Bessède E. Courtois S, et al. Among authors: duran rv. Eur J Cancer. 2017 Oct;84:193-201. doi: 10.1016/j.ejca.2017.07.020. Epub 2017 Aug 17. Eur J Cancer. 2017. PMID: 28822889
mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells.
Nguyen TL, Nokin MJ, Egorov M, Tomé M, Bodineau C, Di Primo C, Minder L, Wdzieczak-Bakala J, Garcia-Alvarez MC, Bignon J, Thoison O, Delpech B, Surpateanu G, Frapart YM, Peyrot F, Abbas K, Terés S, Evrard S, Khatib AM, Soubeyran P, Iorga BI, Durán RV, Collin P. Nguyen TL, et al. Among authors: duran rv. Cancer Res. 2018 Sep 15;78(18):5384-5397. doi: 10.1158/0008-5472.CAN-18-0232. Epub 2018 Jul 27. Cancer Res. 2018. PMID: 30054335
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Soulet F, Bodineau C, Hooks KB, Descarpentrie J, Alves I, Dubreuil M, Mouchard A, Eugenie M, Hoepffner JL, López JJ, Rosado JA, Soubeyran I, Tomé M, Durán RV, Nikolski M, Villoutreix BO, Evrard S, Siegfried G, Khatib AM. Soulet F, et al. Among authors: duran rv. JCI Insight. 2020 Jul 23;5(14):e129070. doi: 10.1172/jci.insight.129070. JCI Insight. 2020. PMID: 32516140 Free PMC article.
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Nguyen TL, et al. Among authors: duran rv. Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13. Mol Oncol. 2021. PMID: 33314742 Free PMC article.
Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression.
Cabré N, Luciano-Mateo F, Chapski DJ, Baiges-Gaya G, Fernández-Arroyo S, Hernández-Aguilera A, Castañé H, Rodríguez-Tomàs E, París M, Sabench F, Del Castillo D, Del Bas JM, Tomé M, Bodineau C, Sola-García A, López-Miranda J, Martín-Montalvo A, Durán RV, Vondriska TM, Rosa-Garrido M, Camps J, Menéndez JA, Joven J. Cabré N, et al. Among authors: duran rv. J Hepatol. 2021 May 4:S0168-8278(21)00302-0. doi: 10.1016/j.jhep.2021.04.037. Online ahead of print. J Hepatol. 2021. PMID: 33961941 Free article.
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