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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. Deprez-Poulain R, et al. Among authors: duplan i. Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250. Nat Commun. 2015. PMID: 26394692 Free PMC article.
Identification of indole-based activators of insulin degrading enzyme.
Kraupner N, Dinh CP, Wen X, Landry V, Herledan A, Leroux F, Bosc D, Charton J, Maillard C, Warenghem S, Duplan I, Piveteau C, Hennuyer N, Staels B, Deprez B, Deprez-Poulain R. Kraupner N, et al. Among authors: duplan i. Eur J Med Chem. 2022 Jan 15;228:113982. doi: 10.1016/j.ejmech.2021.113982. Epub 2021 Nov 16. Eur J Med Chem. 2022. PMID: 34815130
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
Lasalle M, Hoguet V, Hennuyer N, Leroux F, Piveteau C, Belloy L, Lestavel S, Vallez E, Dorchies E, Duplan I, Sevin E, Culot M, Gosselet F, Boulahjar R, Herledan A, Staels B, Deprez B, Tailleux A, Charton J. Lasalle M, et al. Among authors: duplan i. J Med Chem. 2017 May 25;60(10):4185-4211. doi: 10.1021/acs.jmedchem.6b01873. Epub 2017 May 5. J Med Chem. 2017. PMID: 28414465 Free article.
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Hoguet V, Lasalle M, Maingot M, Dequirez G, Boulahjar R, Leroux F, Piveteau C, Herledan A, Biela A, Dumont J, Chávez-Talavera O, Belloy L, Duplan I, Hennuyer N, Butruille L, Lestavel S, Sevin E, Culot M, Gosselet F, Staels B, Deprez B, Tailleux A, Charton J. Hoguet V, et al. Among authors: duplan i. J Med Chem. 2021 Feb 11;64(3):1593-1610. doi: 10.1021/acs.jmedchem.0c01774. Epub 2021 Jan 20. J Med Chem. 2021. PMID: 33470812
The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis.
Hennuyer N, Duplan I, Paquet C, Vanhoutte J, Woitrain E, Touche V, Colin S, Vallez E, Lestavel S, Lefebvre P, Staels B. Hennuyer N, et al. Among authors: duplan i. Atherosclerosis. 2016 Jun;249:200-8. doi: 10.1016/j.atherosclerosis.2016.03.003. Epub 2016 Mar 4. Atherosclerosis. 2016. PMID: 27108950
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation.
Bosviel R, Joumard-Cubizolles L, Chinetti-Gbaguidi G, Bayle D, Copin C, Hennuyer N, Duplan I, Staels B, Zanoni G, Porta A, Balas L, Galano JM, Oger C, Mazur A, Durand T, Gladine C. Bosviel R, et al. Among authors: duplan i. Free Radic Biol Med. 2017 Feb;103:146-154. doi: 10.1016/j.freeradbiomed.2016.12.018. Epub 2016 Dec 14. Free Radic Biol Med. 2017. PMID: 27988338
Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Picon S, Boulahjar R, Hoguet V, Baron M, Duplan I, Vallez E, Hennuyer N, Dumont J, Touche V, Dorchies E, Lasalle M, Descat A, Piveteau C, Biela A, Chaput L, Villoutreix BO, Lipka E, Sevin E, Culot M, Gosselet F, Lestavel S, Roussel P, Deprez-Poulain R, Leroux F, Staels B, Deprez B, Tailleux A, Charton J. Picon S, et al. Among authors: duplan i. J Med Chem. 2023 Sep 14;66(17):11732-11760. doi: 10.1021/acs.jmedchem.2c01881. Epub 2023 Aug 28. J Med Chem. 2023. PMID: 37639383
Anti-inflammatory effects and improved metabolic derangements in ob/ob mice by a newly synthesized prenylated benzopyran with pan-PPAR activity.
Marques P, Villarroel-Vicente C, Collado A, García A, Vila L, Duplan I, Hennuyer N, Garibotto F, Enriz RD, Dacquet C, Staels B, Piqueras L, Cortes D, Sanz MJ, Cabedo N. Marques P, et al. Among authors: duplan i. Pharmacol Res. 2023 Jan;187:106638. doi: 10.1016/j.phrs.2022.106638. Epub 2022 Dec 28. Pharmacol Res. 2023. PMID: 36586645 Free article.