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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.
Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD. Plovier H, et al. Among authors: duparc t. Nat Med. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28. Nat Med. 2017. PMID: 27892954 Free article. Clinical Trial.
Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice.
Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C. Duparc T, et al. Antioxid Redox Signal. 2011 Sep 15;15(6):1477-96. doi: 10.1089/ars.2010.3454. Epub 2011 May 25. Antioxid Redox Signal. 2011. PMID: 21395477
Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes.
Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C. Drougard A, et al. Among authors: duparc t. Antioxid Redox Signal. 2014 Feb 1;20(4):557-73. doi: 10.1089/ars.2013.5182. Epub 2013 Sep 18. Antioxid Redox Signal. 2014. PMID: 23879244 Free PMC article.
Gut microbiota, enteroendocrine functions and metabolism.
Cani PD, Everard A, Duparc T. Cani PD, et al. Among authors: duparc t. Curr Opin Pharmacol. 2013 Dec;13(6):935-40. doi: 10.1016/j.coph.2013.09.008. Epub 2013 Sep 24. Curr Opin Pharmacol. 2013. PMID: 24075718 Review.
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status.
Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD. Everard A, et al. Among authors: duparc t. Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648. Nat Commun. 2014. PMID: 25476696 Free PMC article.
Apelin targets gut contraction to control glucose metabolism via the brain.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C. Fournel A, et al. Among authors: duparc t. Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12. Gut. 2017. PMID: 26565000 Free PMC article.
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.
Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, Ståhlman M, Matamoros S, Geurts L, Pardo-Tendero MM, Druart C, Delzenne NM, Demoulin JB, van der Merwe SW, van Pelt J, Bäckhed F, Monleon D, Everard A, Cani PD. Duparc T, et al. Gut. 2017 Apr;66(4):620-632. doi: 10.1136/gutjnl-2015-310904. Epub 2016 May 5. Gut. 2017. PMID: 27196572 Free PMC article.
35 results