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Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Qian L, et al. Among authors: dunwoodie s. J Cell Biol. 2011 Jun 27;193(7):1181-96. doi: 10.1083/jcb.201006114. Epub 2011 Jun 20. J Cell Biol. 2011. PMID: 21690310 Free PMC article.
Generation of conditional Cited2 null alleles.
Preis JI, Wise N, Solloway MJ, Harvey RP, Sparrow DB, Dunwoodie SL. Preis JI, et al. Genesis. 2006 Dec;44(12):579-83. doi: 10.1002/dvg.20251. Genesis. 2006. PMID: 17133411
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP. Costa MW, et al. Among authors: dunwoodie sl. PLoS One. 2011;6(9):e24812. doi: 10.1371/journal.pone.0024812. Epub 2011 Sep 12. PLoS One. 2011. PMID: 21931855 Free PMC article.
Gene-environment interaction demonstrates the vulnerability of the embryonic heart.
O'Reilly VC, Lopes Floro K, Shi H, Chapman BE, Preis JI, James AC, Chapman G, Harvey RP, Johnson RS, Grieve SM, Sparrow DB, Dunwoodie SL. O'Reilly VC, et al. Among authors: dunwoodie sl. Dev Biol. 2014 Jul 1;391(1):99-110. doi: 10.1016/j.ydbio.2014.03.005. Epub 2014 Mar 18. Dev Biol. 2014. PMID: 24657234 Free PMC article.
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets.
Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP. Bouveret R, et al. Among authors: dunwoodie sl. Elife. 2015 Jul 6;4:e06942. doi: 10.7554/eLife.06942. Elife. 2015. PMID: 26146939 Free PMC article.
147 results