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Page 1
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.
Dawson A, Zarou MM, Prasad B, Bittencourt-Silvestre J, Zerbst D, Himonas E, Hsieh YC, van Loon I, Blanco GR, Ianniciello A, Kerekes Z, Krishnan V, Agarwal P, Almasoudi H, McCluskey L, Hopcroft LEM, Scott MT, Baquero P, Dunn K, Vetrie D, Copland M, Bhatia R, Coffelt SB, Tiong OS, Wheadon H, Zanivan S, Kirschner K, Helgason GV. Dawson A, et al. Among authors: dunn k. Nat Commun. 2024 Feb 5;15(1):1090. doi: 10.1038/s41467-024-45471-0. Nat Commun. 2024. PMID: 38316788 Free PMC article.
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL. Sinclair A, et al. Among authors: dunn k. Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24. Blood. 2016. PMID: 27222476 Free PMC article.
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.
Abraham SA, Hopcroft LE, Carrick E, Drotar ME, Dunn K, Williamson AJ, Korfi K, Baquero P, Park LE, Scott MT, Pellicano F, Pierce A, Copland M, Nourse C, Grimmond SM, Vetrie D, Whetton AD, Holyoake TL. Abraham SA, et al. Among authors: dunn k. Nature. 2016 Jun 16;534(7607):341-6. doi: 10.1038/nature18288. Epub 2016 Jun 8. Nature. 2016. PMID: 27281222 Free PMC article.
Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition.
Scott MT, Korfi K, Saffrey P, Hopcroft LE, Kinstrie R, Pellicano F, Guenther C, Gallipoli P, Cruz M, Dunn K, Jorgensen HG, Cassels JE, Hamilton A, Crossan A, Sinclair A, Holyoake TL, Vetrie D. Scott MT, et al. Among authors: dunn k. Cancer Discov. 2016 Nov;6(11):1248-1257. doi: 10.1158/2159-8290.CD-16-0263. Epub 2016 Sep 14. Cancer Discov. 2016. PMID: 27630125 Free PMC article.
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors.
Baquero P, Dawson A, Mukhopadhyay A, Kuntz EM, Mitchell R, Olivares O, Ianniciello A, Scott MT, Dunn K, Nicastri MC, Winkler JD, Michie AM, Ryan KM, Halsey C, Gottlieb E, Keaney EP, Murphy LO, Amaravadi RK, Holyoake TL, Helgason GV. Baquero P, et al. Among authors: dunn k. Leukemia. 2019 Apr;33(4):981-994. doi: 10.1038/s41375-018-0252-4. Epub 2018 Sep 5. Leukemia. 2019. PMID: 30185934 Free PMC article.
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.
Kinstrie R, Horne GA, Morrison H, Irvine D, Munje C, Castañeda EG, Moka HA, Dunn K, Cassels JE, Parry N, Clarke CJ, Scott MT, Clark RE, Holyoake TL, Wheadon H, Copland M. Kinstrie R, et al. Among authors: dunn k. Leukemia. 2020 Jun;34(6):1613-1625. doi: 10.1038/s41375-019-0684-5. Epub 2020 Jan 2. Leukemia. 2020. PMID: 31896780 Free PMC article.
Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.
Kinstrie R, Horne GA, Morrison H, Irvine D, Munje C, Castañeda EG, Moka HA, Dunn K, Cassels JE, Parry N, Clarke CJ, Scott MT, Clark RE, Holyoake TL, Wheadon H, Copland M. Kinstrie R, et al. Among authors: dunn k. Leukemia. 2020 Jul;34(7):1975. doi: 10.1038/s41375-020-0721-4. Leukemia. 2020. PMID: 32005922 Free PMC article.
ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy.
Ianniciello A, Zarou MM, Rattigan KM, Scott M, Dawson A, Dunn K, Brabcova Z, Kalkman ER, Nixon C, Michie AM, Copland M, Vetrie D, Ambler M, Saxty B, Helgason GV. Ianniciello A, et al. Among authors: dunn k. Sci Transl Med. 2021 Sep 29;13(613):eabd5016. doi: 10.1126/scitranslmed.abd5016. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586834 Free PMC article.
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.
Rattigan KM, Zarou MM, Brabcova Z, Prasad B, Zerbst D, Sarnello D, Kalkman ER, Ianniciello A, Scott MT, Dunn K, Shokry E, Sumpton D, Copland M, Tardito S, Vande Voorde J, Mussai F, Cheng P, Helgason GV. Rattigan KM, et al. Among authors: dunn k. EMBO Rep. 2023 Oct 9;24(10):e56279. doi: 10.15252/embr.202256279. Epub 2023 Jul 25. EMBO Rep. 2023. PMID: 37489735 Free PMC article.
1,220 results