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Future prospects for human genetics and genomics in drug discovery.
Ghoussaini M, Nelson MR, Dunham I. Ghoussaini M, et al. Among authors: dunham i. Curr Opin Struct Biol. 2023 Jun;80:102568. doi: 10.1016/j.sbi.2023.102568. Epub 2023 Mar 22. Curr Opin Struct Biol. 2023. PMID: 36963162 Free PMC article. Review.
Democratizing knowledge representation with BioCypher.
Lobentanzer S, Aloy P, Baumbach J, Bohar B, Carey VJ, Charoentong P, Danhauser K, Doğan T, Dreo J, Dunham I, Farr E, Fernandez-Torras A, Gyori BM, Hartung M, Hoyt CT, Klein C, Korcsmaros T, Maier A, Mann M, Ochoa D, Pareja-Lorente E, Popp F, Preusse M, Probul N, Schwikowski B, Sen B, Strauss MT, Turei D, Ulusoy E, Waltemath D, Wodke JAH, Saez-Rodriguez J. Lobentanzer S, et al. Among authors: dunham i. Nat Biotechnol. 2023 Aug;41(8):1056-1059. doi: 10.1038/s41587-023-01848-y. Nat Biotechnol. 2023. PMID: 37337100 No abstract available.
Genetic support for FDA-approved drugs over the past decade.
Rusina PV, Falaguera MJ, Romero JMR, McDonagh EM, Dunham I, Ochoa D. Rusina PV, et al. Among authors: dunham i. Nat Rev Drug Discov. 2023 Nov;22(11):864. doi: 10.1038/d41573-023-00158-x. Nat Rev Drug Discov. 2023. PMID: 37803084 No abstract available.
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Barrio-Hernandez I, Schwartzentruber J, Shrivastava A, Del-Toro N, Gonzalez A, Zhang Q, Mountjoy E, Suveges D, Ochoa D, Ghoussaini M, Bradley G, Hermjakob H, Orchard S, Dunham I, Anderson CA, Porras P, Beltrao P. Barrio-Hernandez I, et al. Among authors: dunham i. Nat Genet. 2023 Mar;55(3):389-398. doi: 10.1038/s41588-023-01327-9. Epub 2023 Feb 23. Nat Genet. 2023. PMID: 36823319 Free PMC article.
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt.
Ochoa D, Hercules A, Carmona M, Suveges D, Baker J, Malangone C, Lopez I, Miranda A, Cruz-Castillo C, Fumis L, Bernal-Llinares M, Tsukanov K, Cornu H, Tsirigos K, Razuvayevskaya O, Buniello A, Schwartzentruber J, Karim M, Ariano B, Martinez Osorio RE, Ferrer J, Ge X, Machlitt-Northen S, Gonzalez-Uriarte A, Saha S, Tirunagari S, Mehta C, Roldán-Romero JM, Horswell S, Young S, Ghoussaini M, Hulcoop DG, Dunham I, McDonagh EM. Ochoa D, et al. Among authors: dunham i. Nucleic Acids Res. 2023 Jan 6;51(D1):D1353-D1359. doi: 10.1093/nar/gkac1046. Nucleic Acids Res. 2023. PMID: 36399499 Free PMC article.
193 results