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A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Hagan CL, Johnson RJ, Dhulesia A, Dumoulin M, Dumont J, De Genst E, Christodoulou J, Robinson CV, Dobson CM, Kumita JR. Hagan CL, et al. Among authors: dumoulin m. Protein Eng Des Sel. 2010 Jul;23(7):499-506. doi: 10.1093/protein/gzq023. Epub 2010 Apr 9. Protein Eng Des Sel. 2010. PMID: 20382744 Free PMC article.
A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
De Genst E, Chan PH, Pardon E, Hsu SD, Kumita JR, Christodoulou J, Menzer L, Chirgadze DY, Robinson CV, Muyldermans S, Matagne A, Wyns L, Dobson CM, Dumoulin M. De Genst E, et al. Among authors: dumoulin m. J Phys Chem B. 2013 Oct 24;117(42):13245-13258. doi: 10.1021/jp403425z. Epub 2013 Sep 24. J Phys Chem B. 2013. PMID: 23919586 Free PMC article.
161 results