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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. Deprez-Poulain R, et al. Among authors: dumont j. Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250. Nat Commun. 2015. PMID: 26394692 Free PMC article.
FXR-deficiency confers increased susceptibility to torpor.
Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B. Cariou B, et al. Among authors: dumont j. FEBS Lett. 2007 Nov 13;581(27):5191-8. doi: 10.1016/j.febslet.2007.09.064. Epub 2007 Oct 12. FEBS Lett. 2007. PMID: 17950284 Free article.
Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.
Maingot L, Elbakali J, Dumont J, Bosc D, Cousaert N, Urban A, Deglane G, Villoutreix B, Nagase H, Sperandio O, Leroux F, Deprez B, Deprez-Poulain R. Maingot L, et al. Among authors: dumont j. Eur J Med Chem. 2013 Nov;69:244-61. doi: 10.1016/j.ejmech.2013.08.027. Epub 2013 Aug 30. Eur J Med Chem. 2013. PMID: 24044937
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.
Charton J, Gauriot M, Guo Q, Hennuyer N, Marechal X, Dumont J, Hamdane M, Pottiez V, Landry V, Sperandio O, Flipo M, Buee L, Staels B, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R. Charton J, et al. Among authors: dumont j. Eur J Med Chem. 2014 May 22;79:184-93. doi: 10.1016/j.ejmech.2014.04.009. Epub 2014 Apr 4. Eur J Med Chem. 2014. PMID: 24735644 Free PMC article.
Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Charton J, Gauriot M, Totobenazara J, Hennuyer N, Dumont J, Bosc D, Marechal X, Elbakali J, Herledan A, Wen X, Ronco C, Gras-Masse H, Heninot A, Pottiez V, Landry V, Staels B, Liang WG, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R. Charton J, et al. Among authors: dumont j. Eur J Med Chem. 2015 Jan 27;90:547-67. doi: 10.1016/j.ejmech.2014.12.005. Epub 2014 Dec 4. Eur J Med Chem. 2015. PMID: 25489670 Free PMC article.
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
Letronne F, Laumet G, Ayral AM, Chapuis J, Demiautte F, Laga M, Vandenberghe ME, Malmanche N, Leroux F, Eysert F, Sottejeau Y, Chami L, Flaig A, Bauer C, Dourlen P, Lesaffre M, Delay C, Huot L, Dumont J, Werkmeister E, Lafont F, Mendes T, Hansmannel F, Dermaut B, Deprez B, Hérard AS, Dhenain M, Souedet N, Pasquier F, Tulasne D, Berr C, Hauw JJ, Lemoine Y, Amouyel P, Mann D, Déprez R, Checler F, Hot D, Delzescaux T, Gevaert K, Lambert JC. Letronne F, et al. Among authors: dumont j. EBioMedicine. 2016 Jul;9:278-292. doi: 10.1016/j.ebiom.2016.06.002. Epub 2016 Jun 2. EBioMedicine. 2016. PMID: 27333034 Free PMC article.
High-Throughput Image-Based Aggresome Quantification.
Lesire L, Chaput L, Cruz De Casas P, Rousseau F, Piveteau C, Dumont J, Pointu D, Déprez B, Leroux F. Lesire L, et al. Among authors: dumont j. SLAS Discov. 2020 Aug;25(7):783-791. doi: 10.1177/2472555220919708. Epub 2020 May 25. SLAS Discov. 2020. PMID: 32449635 Free article.
1,167 results