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High throughput metabolic stability screen for lead optimization in drug discovery.
Tong XS, Xu S, Zheng S, Pivnichny JV, Martin J, Dufresne C. Tong XS, et al. Among authors: dufresne c. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 3;833(2):165-73. doi: 10.1016/j.jchromb.2006.01.037. Epub 2006 Feb 28. J Chromatogr B Analyt Technol Biomed Life Sci. 2006. PMID: 16504609
Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.
Balani SK, Xu X, Pratha V, Koss MA, Amin RD, Dufresne C, Miller RR, Arison BH, Doss GA, Chiba M, Freeman A, Holland SD, Schwartz JI, Lasseter KC, Gertz BJ, Isenberg JI, Rogers JD, Lin JH, Baillie TA. Balani SK, et al. Among authors: dufresne c. Drug Metab Dispos. 1997 Nov;25(11):1282-7. Drug Metab Dispos. 1997. PMID: 9351905 Clinical Trial.
174 results