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Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Creek D, Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, Drinkwater N, Vinh N, MacRaild C, Counihan N, Duffy S, Wittlin S, Devine S, Avery V, de Koning-Ward T, Scammells P, McGowan S. Creek D, et al. Among authors: duffy s. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230. doi: 10.21203/rs.3.rs-3251230/v3. Res Sq. 2024. PMID: 38746424 Free PMC article. Preprint.
Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study.
Borrego-Yaniz G, Ortiz-Fernández L, Madrid-Paredes A, Kerick M, Hernández-Rodríguez J, Mackie SL, Vaglio A, Castañeda S, Solans R, Mestre-Torres J, Khalidi N, Langford CA, Ytterberg S, Beretta L, Govoni M, Emmi G, Cimmino MA, Witte T, Neumann T, Holle J, Schönau V, Pugnet G, Papo T, Haroche J, Mahr A, Mouthon L, Molberg Ø, Diamantopoulos AP, Voskuyl A, Daikeler T, Berger CT, Molloy ES, Blockmans D, van Sleen Y, Iles M, Sorensen L, Luqmani R, Reynolds G, Bukhari M, Bhagat S, Ortego-Centeno N, Brouwer E, Lamprecht P, Klapa S, Salvarani C, Merkel PA, Cid MC, González-Gay MA, Morgan AW, Martin J, Márquez A; Spanish GCA Group; UK GCA Consortium; Vasculitis Clinical Research Consortium. Borrego-Yaniz G, et al. Lancet Rheumatol. 2024 May 8:S2665-9913(24)00064-X. doi: 10.1016/S2665-9913(24)00064-X. Online ahead of print. Lancet Rheumatol. 2024. PMID: 38734017 Free article.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: duffy s. mBio. 2024 May 8:e0096624. doi: 10.1128/mbio.00966-24. Online ahead of print. mBio. 2024. PMID: 38717141 Free article.
1,852 results