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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.
Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Souchet B, et al. Among authors: dufayet chaffaud g. Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6. Acta Neuropathol Commun. 2019. PMID: 30885273 Free PMC article.
Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.
Audrain M, Fol R, Dutar P, Potier B, Billard JM, Flament J, Alves S, Burlot MA, Dufayet-Chaffaud G, Bemelmans AP, Valette J, Hantraye P, Déglon N, Cartier N, Braudeau J. Audrain M, et al. Among authors: dufayet chaffaud g. Mol Neurodegener. 2016 Jan 12;11:5. doi: 10.1186/s13024-016-0070-y. Mol Neurodegener. 2016. PMID: 26759118 Free PMC article.
Genetically modified macrophages accelerate myelin repair.
Aigrot MS, Barthelemy C, Moyon S, Dufayet-Chaffaud G, Izagirre-Urizar L, Gillet-Legrand B, Tada S, Bayón-Cordero L, Chara JC, Matute C, Cartier N, Lubetzki C, Tepavčević V. Aigrot MS, et al. Among authors: dufayet chaffaud g. EMBO Mol Med. 2022 Aug 8;14(8):e14759. doi: 10.15252/emmm.202114759. Epub 2022 Jul 13. EMBO Mol Med. 2022. PMID: 35822550 Free PMC article.