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A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.
Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, Di Lisio C, D'Amore S, Bertrand-Michel J, Montagner A, Pineau T, Loiseau N, Lobaccaro JM, Martin PG, Guillou H. Ducheix S, et al. Biochimie. 2013 Mar;95(3):556-67. doi: 10.1016/j.biochi.2012.09.028. Epub 2012 Oct 10. Biochimie. 2013. PMID: 23063693
Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.
Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Al Saati T, Chétiveaux M, Baron S, Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. Ducheix S, et al. J Hepatol. 2013 May;58(5):984-92. doi: 10.1016/j.jhep.2013.01.006. Epub 2013 Jan 16. J Hepatol. 2013. PMID: 23333450
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H. Montagner A, et al. Among authors: ducheix s. Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1. Gut. 2016. PMID: 26838599 Free PMC article.
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L. Marmugi A, et al. Among authors: ducheix s. Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100. doi: 10.1016/j.taap.2016.05.006. Epub 2016 May 11. Toxicol Appl Pharmacol. 2016. PMID: 27180240
Dual extraction of mRNA and lipids from a single biological sample.
Podechard N, Ducheix S, Polizzi A, Lasserre F, Montagner A, Legagneux V, Fouché E, Saez F, Lobaccaro JM, Lakhal L, Ellero-Simatos S, Martin PG, Loiseau N, Bertrand-Michel J, Guillou H. Podechard N, et al. Among authors: ducheix s. Sci Rep. 2018 May 4;8(1):7019. doi: 10.1038/s41598-018-25332-9. Sci Rep. 2018. PMID: 29728575 Free PMC article.
28 results