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Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice.
Cimen I, Natarelli L, Abedi Kichi Z, Henderson JM, Farina FM, Briem E, Aslani M, Megens RTA, Jansen Y, Mann-Fallenbuchel E, Gencer S, Duchêne J, Nazari-Jahantigh M, van der Vorst EPC, Enard W, Döring Y, Schober A, Santovito D, Weber C. Cimen I, et al. Among authors: duchene j. Sci Transl Med. 2023 Nov;15(720):eadf3357. doi: 10.1126/scitranslmed.adf3357. Epub 2023 Nov 1. Sci Transl Med. 2023. PMID: 37910599
Atypical Chemokine Receptors in Cardiovascular Disease.
Gencer S, van der Vorst EPC, Aslani M, Weber C, Döring Y, Duchene J. Gencer S, et al. Among authors: duchene j. Thromb Haemost. 2019 Apr;119(4):534-541. doi: 10.1055/s-0038-1676988. Epub 2019 Feb 4. Thromb Haemost. 2019. PMID: 30716778 Review.
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C. Santovito D, et al. Among authors: duchene j. Sci Transl Med. 2020 Jun 3;12(546):eaaz2294. doi: 10.1126/scitranslmed.aaz2294. Sci Transl Med. 2020. PMID: 32493793
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.
Gencer S, Döring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Müller M, Peters LJF, Megens RTA, von Hundelshausen P, Duchene J, Lemnitzer P, Soehnlein O, Weber C, van der Vorst EPC. Gencer S, et al. Among authors: duchene j. Basic Res Cardiol. 2022 Jun 8;117(1):30. doi: 10.1007/s00395-022-00937-4. Basic Res Cardiol. 2022. PMID: 35674847 Free PMC article.
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.
Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E. Seijkens TTP, et al. Among authors: duchene j. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055. J Am Coll Cardiol. 2018. PMID: 29406859 Free PMC article.
Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development.
van der Vorst EPC, Daissormont I, Aslani M, Seijkens T, Wijnands E, Lutgens E, Duchene J, Santovito D, Döring Y, Halvorsen B, Aukrust P, Weber C, Höpken UE, Biessen EAL. van der Vorst EPC, et al. Among authors: duchene j. Thromb Haemost. 2020 Feb;120(2):344-347. doi: 10.1055/s-0039-3400746. Epub 2019 Dec 14. Thromb Haemost. 2020. PMID: 31837653 No abstract available.
Autophagy unleashes noncanonical microRNA functions.
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C. Santovito D, et al. Among authors: duchene j. Autophagy. 2020 Dec;16(12):2294-2296. doi: 10.1080/15548627.2020.1830523. Epub 2020 Oct 15. Autophagy. 2020. PMID: 33054575 Free PMC article.
Targeting platelet-derived CXCL12 impedes arterial thrombosis.
Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Döring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P. Leberzammer J, et al. Among authors: duchene j. Blood. 2022 Apr 28;139(17):2691-2705. doi: 10.1182/blood.2020010140. Blood. 2022. PMID: 35313337 Free PMC article.
134 results