Du C - Search Results

1

Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.

Machushynets NV, Al Ayed K, Terlouw BR, Du C, Buijs NP, Willemse J, Elsayed SS, Schill J, Trebosc V, Pieren M, Alexander FM, Cochrane SA, Liles MR, Medema MH, Martin NI, van Wezel GP. Machushynets NV, et al. Among authors: du c. ACS Chem Biol. 2024 Apr 11. doi: 10.1021/acschembio.4c00034. Online ahead of print. ACS Chem Biol. 2024. PMID: 38602492

2

Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.

Xiao X, Elsayed SS, Wu C, van der Heul HU, Metsä-Ketelä M, Du C, Prota AE, Chen CC, Liu W, Guo RT, Abrahams JP, van Wezel GP. Xiao X, et al. Among authors: du c. ACS Chem Biol. 2020 Sep 18;15(9):2529-2538. doi: 10.1021/acschembio.0c00564. Epub 2020 Sep 8. ACS Chem Biol. 2020. PMID: 32840360 Free PMC article.

3

Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.

Machushynets NV, Elsayed SS, Du C, Siegler MA, de la Cruz M, Genilloud O, Hankemeier T, van Wezel GP. Machushynets NV, et al. Among authors: du c. Sci Rep. 2022 Feb 18;12(1):2813. doi: 10.1038/s41598-022-06736-0. Sci Rep. 2022. PMID: 35181725 Free PMC article.

4

Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.

Du C, van Wezel GP. Du C, et al. Proteomics. 2018 Sep;18(18):e1700332. doi: 10.1002/pmic.201700332. Epub 2018 Jun 10. Proteomics. 2018. PMID: 29708658 Free PMC article. Review.

5

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides.

Kloosterman AM, Cimermancic P, Elsayed SS, Du C, Hadjithomas M, Donia MS, Fischbach MA, van Wezel GP, Medema MH. Kloosterman AM, et al. Among authors: du c. PLoS Biol. 2020 Dec 22;18(12):e3001026. doi: 10.1371/journal.pbio.3001026. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33351797 Free PMC article.

6

The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes.

van der Meij A, Elsayed SS, Du C, Willemse J, Wood TM, Martin NI, Raaijmakers JM, van Wezel GP. van der Meij A, et al. Among authors: du c. Appl Environ Microbiol. 2023 Nov 29;89(11):e0123923. doi: 10.1128/aem.01239-23. Epub 2023 Oct 30. Appl Environ Microbiol. 2023. PMID: 37902333 Free PMC article.

7

Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced by Streptomyces Species MBT28.

Wu C, Du C, Gubbens J, Choi YH, van Wezel GP. Wu C, et al. Among authors: du c. J Nat Prod. 2015 Oct 23;78(10):2355-63. doi: 10.1021/acs.jnatprod.5b00276. Epub 2015 Oct 6. J Nat Prod. 2015. PMID: 26438963

8

System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact on Streptomyces Development.

Du C, Willemse J, Erkelens AM, Carrion VJ, Dame RT, van Wezel GP. Du C, et al. mSystems. 2022 Jun 28;7(3):e0006122. doi: 10.1128/msystems.00061-22. Epub 2022 May 16. mSystems. 2022. PMID: 35575488 Free PMC article.

9

Artificial intelligence for natural product drug discovery.

Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Mullowney MW, et al. Among authors: du c. Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11. Nat Rev Drug Discov. 2023. PMID: 37697042 Review.

10

Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow.

Wu C, Du C, Ichinose K, Choi YH, van Wezel GP. Wu C, et al. Among authors: du c. J Nat Prod. 2017 Feb 24;80(2):269-277. doi: 10.1021/acs.jnatprod.6b00478. Epub 2017 Jan 27. J Nat Prod. 2017. PMID: 28128554 Free PMC article.

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