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Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice.
Kuchař M, Kosztyu P, Daniel Lišková V, Černý J, Petroková H, Vróblová E, Malý M, Vaňková L, Křupka M, Rašková Kafková L, Turánek Knotigová P, Dušková J, Dohnálek J, Mašek J, Turánek J, Raška M, Malý P. Kuchař M, et al. Among authors: duskova j. Virulence. 2021 Dec;12(1):1271-1287. doi: 10.1080/21505594.2021.1920251. Virulence. 2021. PMID: 33993840 Free PMC article.
A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease.
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Dohnálek J, et al. Among authors: duskova j. Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):472-6. doi: 10.1107/s0907444900018928. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11223536
Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor.
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Dohnálek J, et al. Among authors: duskova j. J Med Chem. 2002 Mar 28;45(7):1432-8. doi: 10.1021/jm010979e. J Med Chem. 2002. PMID: 11906284
On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution.
Dusková J, Dohnálek J, Skálová T, Petroková H, Vondrácková E, Hradílek M, Konvalinka J, Soucek M, Brynda J, Fábry M, Sedlácek J, Hasek J. Dusková J, et al. Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):489-97. doi: 10.1107/S0907444906006718. Epub 2006 Apr 19. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 16627941
Excretome of the chitinolytic bacterium Clostridium paraputrificum J4.
Simůnek J, Koppová I, Tiščenko G, Dohnálek J, Dušková J. Simůnek J, et al. Among authors: duskova j. Folia Microbiol (Praha). 2012 Jul;57(4):335-9. doi: 10.1007/s12223-012-0137-2. Epub 2012 Apr 20. Folia Microbiol (Praha). 2012. PMID: 22528309
210 results