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The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51.
Antunica-Noguerol M, Budziñski ML, Druker J, Gassen NC, Sokn MC, Senin S, Aprile-Garcia F, Holsboer F, Rein T, Liberman AC, Arzt E. Antunica-Noguerol M, et al. Among authors: druker j. Cell Death Differ. 2016 Oct;23(10):1579-91. doi: 10.1038/cdd.2016.44. Epub 2016 May 13. Cell Death Differ. 2016. PMID: 27177020 Free PMC article.
The serine/arginine-rich protein SF2/ASF regulates protein sumoylation.
Pelisch F, Gerez J, Druker J, Schor IE, Muñoz MJ, Risso G, Petrillo E, Westman BJ, Lamond AI, Arzt E, Srebrow A. Pelisch F, et al. Among authors: druker j. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16119-24. doi: 10.1073/pnas.1004653107. Epub 2010 Aug 30. Proc Natl Acad Sci U S A. 2010. PMID: 20805487 Free PMC article.
Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.
Liberman AC, Antunica-Noguerol M, Ferraz-de-Paula V, Palermo-Neto J, Castro CN, Druker J, Holsboer F, Perone MJ, Gerlo S, De Bosscher K, Haegeman G, Arzt E. Liberman AC, et al. Among authors: druker j. PLoS One. 2012;7(4):e35155. doi: 10.1371/journal.pone.0035155. Epub 2012 Apr 9. PLoS One. 2012. PMID: 22496903 Free PMC article.
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