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Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
Sci Transl Med. 2022 Oct 5;14(665):eabn1716. doi: 10.1126/scitranslmed.abn1716. Epub 2022 Oct 5.
Sci Transl Med. 2022.
PMID: 36197963
Pancreatic Stellate Cells Prolong Ex Vivo Islet Viability and Function and Improve Engraftment.
Paul PK, Das R, Drow TJ, de Souza AH, Balamurugan AN, Belt Davis D, Galipeau J.
Paul PK, et al. Among authors: drow tj.
Stem Cells Transl Med. 2022 Jun 22;11(6):630-643. doi: 10.1093/stcltm/szac018.
Stem Cells Transl Med. 2022.
PMID: 35438788
Free PMC article.
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Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression.
Paul PK, Das R, Drow T, Nylen EA, de Souza AH, Wang Z, Wood MW, Davis DB, Bjorling DE, Galipeau J.
Paul PK, et al. Among authors: drow t.
Am J Transplant. 2022 Nov;22(11):2571-2585. doi: 10.1111/ajt.17162. Epub 2022 Aug 3.
Am J Transplant. 2022.
PMID: 35897156
Free PMC article.
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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.
Uenishi GI, Repic M, Yam JY, Landuyt A, Saikumar-Lakshmi P, Guo T, Zarin P, Sassone-Corsi M, Chicoine A, Kellogg H, Hunt M, Drow T, Tewari R, Cook PJ, Yang SJ, Cerosaletti K, Schweinoch D, Guiastrennec B, James E, Patel C, Chen TF, Buckner JH, Rawlings DJ, Wickham TJ, Mueller KT.
Uenishi GI, et al. Among authors: drow t.
JCI Insight. 2024 Feb 8;9(6):e171844. doi: 10.1172/jci.insight.171844.
JCI Insight. 2024.
PMID: 38516892
Free PMC article.
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Activated PI3Kδ specifically perturbs mouse Treg homeostasis and function leading to immune dysregulation.
Singh AK, Qureshah FA, Drow T, Hou B, Rawlings DJ.
Singh AK, et al. Among authors: drow t.
bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.569665. doi: 10.1101/2023.12.21.569665.
bioRxiv. 2023.
PMID: 38187650
Free PMC article.
Preprint.
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A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells.
Cook PJ, Yang SJ, Uenishi GI, Grimm A, West SE, Wang LJ, Jacobs C, Repele A, Drow T, Boukhris A, Dahl NP, Sommer K, Scharenberg AM, Rawlings DJ.
Cook PJ, et al. Among authors: drow t.
Mol Ther. 2023 Aug 2;31(8):2472-2488. doi: 10.1016/j.ymthe.2023.04.021. Epub 2023 May 4.
Mol Ther. 2023.
PMID: 37147803
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Corrigendum to "Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression" [American Journal of Transplantation (2022) 2571-2585].
Paul PK, Das R, Drow T, Nylen EA, Henrique de Souza A, Wang Z, Wood MW, Davis DB, Bjorling DE, Galipeau J.
Paul PK, et al. Among authors: drow t.
Am J Transplant. 2023 May;23(5):693. doi: 10.1016/j.ajt.2023.02.019. Epub 2023 Mar 6.
Am J Transplant. 2023.
PMID: 36907701
Free PMC article.
No abstract available.
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