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Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.
Yao Z, Yaeger R, Rodrik-Outmezguine VS, Tao A, Torres NM, Chang MT, Drosten M, Zhao H, Cecchi F, Hembrough T, Michels J, Baumert H, Miles L, Campbell NM, de Stanchina E, Solit DB, Barbacid M, Taylor BS, Rosen N. Yao Z, et al. Among authors: drosten m. Nature. 2017 Aug 10;548(7666):234-238. doi: 10.1038/nature23291. Epub 2017 Aug 2. Nature. 2017. PMID: 28783719 Free PMC article.
Using cells devoid of RAS proteins as tools for drug discovery.
Urosevic J, Sum EY, Moneo V, Drosten M, Dhawahir A, Becerra M, Carnero A, Barbacid M. Urosevic J, et al. Among authors: drosten m. Mol Carcinog. 2009 Nov;48(11):1038-47. doi: 10.1002/mc.20555. Mol Carcinog. 2009. PMID: 19526460
Ras signaling is essential for skin development.
Drosten M, Lechuga CG, Barbacid M. Drosten M, et al. Oncogene. 2014 May 29;33(22):2857-65. doi: 10.1038/onc.2013.254. Epub 2013 Jul 8. Oncogene. 2014. PMID: 23831572
Ras in epidermal proliferation.
Drosten M, Lechuga CG, Barbacid M. Drosten M, et al. Oncotarget. 2014 Jul 30;5(14):5194-5. doi: 10.18632/oncotarget.2275. Oncotarget. 2014. PMID: 25114036 Free PMC article. No abstract available.
43 results