Drohat AC - Search Results

1

Characterizing inhibitors of human AP endonuclease 1.

Pidugu LS, Servius HW, Sevdalis SE, Cook ME, Varney KM, Pozharski E, Drohat AC. Pidugu LS, et al. Among authors: drohat ac. PLoS One. 2023 Jan 18;18(1):e0280526. doi: 10.1371/journal.pone.0280526. eCollection 2023. PLoS One. 2023. PMID: 36652434 Free PMC article.

2

Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.

Maiti A, Morgan MT, Pozharski E, Drohat AC. Maiti A, et al. Among authors: drohat ac. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8890-5. doi: 10.1073/pnas.0711061105. Epub 2008 Jun 27. Proc Natl Acad Sci U S A. 2008. PMID: 18587051 Free PMC article.

3

Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.

Fitzgerald ME, Drohat AC. Fitzgerald ME, et al. Among authors: drohat ac. J Biol Chem. 2008 Nov 21;283(47):32680-90. doi: 10.1074/jbc.M805504200. Epub 2008 Sep 19. J Biol Chem. 2008. PMID: 18805789 Free PMC article.

4

Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1.

Manvilla BA, Varney KM, Drohat AC. Manvilla BA, et al. Among authors: drohat ac. Biomol NMR Assign. 2010 Apr;4(1):5-8. doi: 10.1007/s12104-009-9196-y. Epub 2009 Nov 4. Biomol NMR Assign. 2010. PMID: 19888678 Free PMC article.

5

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

Manvilla BA, Wauchope O, Seley-Radtke KL, Drohat AC. Manvilla BA, et al. Among authors: drohat ac. Biochemistry. 2011 Dec 6;50(48):10540-9. doi: 10.1021/bi201071g. Epub 2011 Nov 9. Biochemistry. 2011. PMID: 22032234 Free PMC article.

6

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.

Maiti A, Noon MS, MacKerell AD Jr, Pozharski E, Drohat AC. Maiti A, et al. Among authors: drohat ac. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8091-6. doi: 10.1073/pnas.1201010109. Epub 2012 May 9. Proc Natl Acad Sci U S A. 2012. PMID: 22573813 Free PMC article.

7

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA.

Drohat AC, Pozharski E, Maiti A. Drohat AC, et al. Cell Cycle. 2012 Sep 15;11(18):3345-6. doi: 10.4161/cc.21843. Epub 2012 Aug 23. Cell Cycle. 2012. PMID: 22918241 Free PMC article.

8

Functional assessment of population and tumor-associated APE1 protein variants.

Illuzzi JL, Harris NA, Manvilla BA, Kim D, Li M, Drohat AC, Wilson DM 3rd. Illuzzi JL, et al. Among authors: drohat ac. PLoS One. 2013 Jun 11;8(6):e65922. doi: 10.1371/journal.pone.0065922. Print 2013. PLoS One. 2013. PMID: 23776569 Free PMC article.

9

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

Luncsford PJ, Manvilla BA, Patterson DN, Malik SS, Jin J, Hwang BJ, Gunther R, Kalvakolanu S, Lipinski LJ, Yuan W, Lu W, Drohat AC, Lu AL, Toth EA. Luncsford PJ, et al. Among authors: drohat ac. DNA Repair (Amst). 2013 Dec;12(12):1043-52. doi: 10.1016/j.dnarep.2013.09.007. Epub 2013 Oct 24. DNA Repair (Amst). 2013. PMID: 24209961 Free PMC article.

10

Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+ cofactor.

Manvilla BA, Pozharski E, Toth EA, Drohat AC. Manvilla BA, et al. Among authors: drohat ac. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2555-62. doi: 10.1107/S0907444913027042. Epub 2013 Nov 19. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 24311596 Free PMC article.

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