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Arylsulfonamide pyrimidines as VLA-4 antagonists.
Xu YZ, Konradi AW, Bard F, Dappen M, Dofiles L, Dreyer M, Gallager I, Garrido C, Krimm M, Liao Z, Messersmith E, Mutter L, Pleiss MA, Samant B, Semko CM, Smith J, Stappenbeck F, Stupi B, Vandervert C, Welch B, Wipke B, Yednock T. Xu YZ, et al. Among authors: dreyer m. Bioorg Med Chem Lett. 2013 May 15;23(10):3070-4. doi: 10.1016/j.bmcl.2013.03.010. Epub 2013 Mar 15. Bioorg Med Chem Lett. 2013. PMID: 23562062
Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model.
Semko CM, Chen L, Dressen DB, Dreyer ML, Dunn W, Farouz FS, Freedman SB, Holsztynska EJ, Jefferies M, Konradi AW, Liao A, Lugar J, Mutter L, Pleiss MA, Quinn KP, Thompson T, Thorsett ED, Vandevert C, Xu YZ, Yednock TA. Semko CM, et al. Among authors: dreyer ml. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1741-3. doi: 10.1016/j.bmcl.2011.01.075. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316228
Orally available and efficacious α4β1/α4β7 integrin inhibitors.
Xu YZ, Smith JL, Semko CM, Rossiter KI, Fukuda JY, Dappen MS, Quincy DA, Konradi AW, Mao W, Welch B, Dreyer ML, Samant B, Zhang H, Lugar J, Liao Z, Henschel C, Petersen E, Vandevert C, Shoemaker M, Wehner N, Mutter L, Shopp G, Krimm M, Chen L, Wipke B, Dofiles L, Gallager I, Sauer JM, Messersmith EK, Pleiss MA, Bard F, Yednock TA. Xu YZ, et al. Among authors: dreyer ml. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4370-3. doi: 10.1016/j.bmcl.2013.05.076. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23777782
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
Hawkinson JE, Szoke BG, Garofalo AW, Hom DS, Zhang H, Dreyer M, Fukuda JY, Chen L, Samant B, Simmonds S, Zeitz KP, Wadsworth A, Liao A, Chavez RA, Zmolek W, Ruslim L, Bova MP, Holcomb R, Butelman ER, Ko MC, Malmberg AB. Hawkinson JE, et al. Among authors: dreyer m. J Pharmacol Exp Ther. 2007 Aug;322(2):619-30. doi: 10.1124/jpet.107.120352. Epub 2007 Apr 30. J Pharmacol Exp Ther. 2007. PMID: 17470643
Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin.
Zhan H, Liu B, Reid SW, Aoki KH, Li C, Syed RS, Karkaria C, Koe G, Sitney K, Hayenga K, Mistry F, Savel L, Dreyer M, Katz BA, Schreurs J, Matthews DJ, Cheetham JC, Egrie J, Giebel LB, Stroud RM. Zhan H, et al. Among authors: dreyer m. Protein Eng. 1999 Jun;12(6):505-13. doi: 10.1093/protein/12.6.505. Protein Eng. 1999. PMID: 10388848
Interactions of mast cell tryptase with thrombin receptors and PAR-2.
Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF. Molino M, et al. Among authors: dreyer m. J Biol Chem. 1997 Feb 14;272(7):4043-9. doi: 10.1074/jbc.272.7.4043. J Biol Chem. 1997. PMID: 9020112 Free article.
Cryogenic propellant management in space: open challenges and perspectives.
Simonini A, Dreyer M, Urbano A, Sanfedino F, Himeno T, Behruzi P, Avila M, Pinho J, Peveroni L, Gouriet JB. Simonini A, et al. Among authors: dreyer m. NPJ Microgravity. 2024 Mar 20;10(1):34. doi: 10.1038/s41526-024-00377-5. NPJ Microgravity. 2024. PMID: 38509131 Free PMC article. Review.
296 results