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A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.
D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. D'Ippolito RA, et al. Among authors: drew mr. Anal Chem. 2024 Apr 2;96(13):5223-5231. doi: 10.1021/acs.analchem.3c05626. Epub 2024 Mar 18. Anal Chem. 2024. PMID: 38498381 Free PMC article.
Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.
Sherekar M, Han SW, Ghirlando R, Messing S, Drew M, Rabara D, Waybright T, Juneja P, O'Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV, Gillette W, McCormick F, Esposito D. Sherekar M, et al. J Biol Chem. 2020 Jan 24;295(4):1105-1119. doi: 10.1074/jbc.RA119.010934. Epub 2019 Dec 13. J Biol Chem. 2020. PMID: 31836666 Free PMC article.
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. Van QN, et al. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24258-24268. doi: 10.1073/pnas.2006504117. Epub 2020 Sep 10. Proc Natl Acad Sci U S A. 2020. PMID: 32913056 Free PMC article.
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. Young LC, et al. Among authors: drew m. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208960120. doi: 10.1073/pnas.2208960120. Epub 2023 Jan 23. Proc Natl Acad Sci U S A. 2023. PMID: 36689660 Free PMC article.
76 results