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Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors.
Lemech C, Dredge K, Bampton D, Hammond E, Clouston A, Waterhouse NJ, Stanley AC, Leveque-El Mouttie L, Chojnowski GM, Haydon A, Pavlakis N, Burge M, Brown MP, Goldstein D. Lemech C, et al. Among authors: dredge k. J Immunother Cancer. 2023 Jan;11(1):e006136. doi: 10.1136/jitc-2022-006136. J Immunother Cancer. 2023. PMID: 36634920 Free PMC article. Clinical Trial.
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: dredge k. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis.
Buitrago G, Pickering D, Ruscher R, Cobos Caceres C, Jones L, Cooper M, Van Waardenberg A, Ryan S, Miles K, Field M, Dredge K, Daly NL, Giacomin PR, Loukas A. Buitrago G, et al. Among authors: dredge k. Transl Res. 2021 Jun;232:88-102. doi: 10.1016/j.trsl.2021.02.012. Epub 2021 Mar 4. Transl Res. 2021. PMID: 33676036 Free article.
Correction: The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.
Jung DB, Yun M, Kim EO, Kim J, Kim B, Jung JH, Wang E, Mukopadhyay D, Hammond E, Dredge K, Shridhar V, Kim SH. Jung DB, et al. Among authors: dredge k. Oncotarget. 2019 Sep 24;10(54):5669. doi: 10.18632/oncotarget.27216. eCollection 2019 Sep 24. Oncotarget. 2019. PMID: 31608142 Free PMC article.
51 results