Drayson MT - Search Results

1

Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques.

Denbigh JL, Perez-Guaita D, Vernooij RR, Tobin MJ, Bambery KR, Xu Y, Southam AD, Khanim FL, Drayson MT, Lockyer NP, Goodacre R, Wood BR. Denbigh JL, et al. Among authors: drayson mt. Sci Rep. 2017 Jun 1;7(1):2649. doi: 10.1038/s41598-017-02069-5. Sci Rep. 2017. PMID: 28572622 Free PMC article.

2

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids.

Southam AD, Khanim FL, Hayden RE, Constantinou JK, Koczula KM, Michell RH, Viant MR, Drayson MT, Bunce CM. Southam AD, et al. Among authors: drayson mt. Cancer Res. 2015 Jun 15;75(12):2530-40. doi: 10.1158/0008-5472.CAN-15-0202. Epub 2015 May 5. Cancer Res. 2015. PMID: 25943877

3

Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing.

Jiang Y, Southam AD, Trova S, Beke F, Alhazmi B, Francis T, Radotra A, di Maio A, Drayson MT, Bunce CM, Khanim FL. Jiang Y, et al. Among authors: drayson mt. Br J Cancer. 2022 Feb;126(2):275-286. doi: 10.1038/s41416-021-01570-z. Epub 2021 Oct 22. Br J Cancer. 2022. PMID: 34686779 Free PMC article.

4

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia.

Khanim FL, Hayden RE, Birtwistle J, Lodi A, Tiziani S, Davies NJ, Ride JP, Viant MR, Gunther UL, Mountford JC, Schrewe H, Green RM, Murray JA, Drayson MT, Bunce CM. Khanim FL, et al. Among authors: drayson mt. PLoS One. 2009 Dec 7;4(12):e8147. doi: 10.1371/journal.pone.0008147. PLoS One. 2009. PMID: 19997560 Free PMC article.

5

Does the pursuit of scientific excellence serve or hamper translational medical research: an historical perspective from hematological malignancies.

Bunce CM, Khanim FL, Drayson MT. Bunce CM, et al. Among authors: drayson mt. Blood Cancer J. 2022 Oct 7;12(10):142. doi: 10.1038/s41408-022-00738-x. Blood Cancer J. 2022. PMID: 36202796 Free PMC article. Review.

6

Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML).

Murray JA, Khanim FL, Hayden RE, Craddock CF, Holyoake TL, Jackson N, Lumley M, Bunce CM, Drayson MT. Murray JA, et al. Among authors: drayson mt. Br J Haematol. 2010 Apr;149(1):65-9. doi: 10.1111/j.1365-2141.2009.08055.x. Epub 2010 Jan 13. Br J Haematol. 2010. PMID: 20067564 Free article. Clinical Trial.

7

Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone.

Lilly AJ, Khanim FL, Hayden RE, Luong QT, Drayson MT, Bunce CM. Lilly AJ, et al. Among authors: drayson mt. Cancer Res. 2011 Feb 1;71(3):1177-86. doi: 10.1158/0008-5472.CAN-10-1704. Epub 2010 Dec 17. Cancer Res. 2011. PMID: 21169412

8

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

Bradbury CA, Khanim FL, Hayden R, Bunce CM, White DA, Drayson MT, Craddock C, Turner BM. Bradbury CA, et al. Among authors: drayson mt. Leukemia. 2005 Oct;19(10):1751-9. doi: 10.1038/sj.leu.2403910. Leukemia. 2005. PMID: 16121216

9

Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation.

Lodi A, Tiziani S, Khanim FL, Drayson MT, Günther UL, Bunce CM, Viant MR. Lodi A, et al. Among authors: drayson mt. ACS Chem Biol. 2011 Feb 18;6(2):169-75. doi: 10.1021/cb900300j. Epub 2010 Oct 18. ACS Chem Biol. 2011. PMID: 20886892 Free PMC article.

10

Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2.

Hayden RE, Pratt G, Davies NJ, Khanim FL, Birtwistle J, Delgado J, Pearce C, Sant T, Drayson MT, Bunce CM. Hayden RE, et al. Among authors: drayson mt. Leukemia. 2009 Feb;23(2):292-304. doi: 10.1038/leu.2008.283. Epub 2008 Oct 16. Leukemia. 2009. PMID: 18923439

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