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(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells.
Stefela A, Kaspar M, Drastik M, Kronenberger T, Micuda S, Dracinsky M, Klepetarova B, Kudova E, Pavek P. Stefela A, et al. Among authors: drastik m. Front Pharmacol. 2021 Aug 13;12:713149. doi: 10.3389/fphar.2021.713149. eCollection 2021. Front Pharmacol. 2021. PMID: 34483922 Free PMC article.
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol.
Rashidian A, Dušek J, Drastik M, Smutná L, Fritsche K, Braeuning A, Pijnenburg D, van Beuningen R, Honkakoski P, Poso A, Kronenberger T, Pavek P. Rashidian A, et al. Among authors: drastik m. Environ Sci Technol. 2024 Apr 23;58(16):6913-6923. doi: 10.1021/acs.est.3c10096. Epub 2024 Apr 9. Environ Sci Technol. 2024. PMID: 38593436