Drakakis G - Search Results

1

Jaqpot Quattro: A Novel Computational Web Platform for Modeling and Analysis in Nanoinformatics.

Chomenidis C, Drakakis G, Tsiliki G, Anagnostopoulou E, Valsamis A, Doganis P, Sopasakis P, Sarimveis H. Chomenidis C, et al. Among authors: drakakis g. J Chem Inf Model. 2017 Sep 25;57(9):2161-2172. doi: 10.1021/acs.jcim.7b00223. Epub 2017 Sep 11. J Chem Inf Model. 2017. PMID: 28812890 Free article.

2

Decision Trees for Continuous Data and Conditional Mutual Information as a Criterion for Splitting Instances.

Drakakis G, Moledina S, Chomenidis C, Doganis P, Sarimveis H. Drakakis G, et al. Comb Chem High Throughput Screen. 2016;19(5):423-8. doi: 10.2174/1386207319666160414105217. Comb Chem High Throughput Screen. 2016. PMID: 27074759

3

Comparing global and local likelihood score thresholds in multiclass laplacian-modified Naive Bayes protein target prediction.

Drakakis G, Koutsoukas A, Brewerton SC, Bodkin MJ, Evans DA, Bender A. Drakakis G, et al. Comb Chem High Throughput Screen. 2015;18(3):323-30. doi: 10.2174/1386207318666150305145012. Comb Chem High Throughput Screen. 2015. PMID: 25747441

4

Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes.

Mohamad Zobir SZ, Mohd Fauzi F, Liggi S, Drakakis G, Fu X, Fan TP, Bender A. Mohamad Zobir SZ, et al. Among authors: drakakis g. Evid Based Complement Alternat Med. 2016;2016:2106465. doi: 10.1155/2016/2106465. Epub 2016 Feb 18. Evid Based Complement Alternat Med. 2016. PMID: 26989424 Free PMC article.

5

Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.

Liggi S, Drakakis G, Koutsoukas A, Cortes-Ciriano I, Martínez-Alonso P, Malliavin TE, Velazquez-Campoy A, Brewerton SC, Bodkin MJ, Evans DA, Glen RC, Carrodeguas JA, Bender A. Liggi S, et al. Among authors: drakakis g. Future Med Chem. 2014;6(18):2029-56. doi: 10.4155/fmc.14.137. Future Med Chem. 2014. PMID: 25531967 Free article.

6

Diversity selection of compounds based on 'protein affinity fingerprints' improves sampling of bioactive chemical space.

Nguyen HP, Koutsoukas A, Mohd Fauzi F, Drakakis G, Maciejewski M, Glen RC, Bender A. Nguyen HP, et al. Among authors: drakakis g. Chem Biol Drug Des. 2013 Sep;82(3):252-66. doi: 10.1111/cbdd.12155. Chem Biol Drug Des. 2013. PMID: 23647865

7

Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.

Ravindranath AC, Perualila-Tan N, Kasim A, Drakakis G, Liggi S, Brewerton SC, Mason D, Bodkin MJ, Evans DA, Bhagwat A, Talloen W, Göhlmann HW, Shkedy Z, Bender A; QSTAR Consortium. Ravindranath AC, et al. Among authors: drakakis g. Mol Biosyst. 2015 Jan;11(1):86-96. doi: 10.1039/c4mb00328d. Epub 2014 Sep 25. Mol Biosyst. 2015. PMID: 25254964

8

Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readouts.

Liggi S, Drakakis G, Hendry AE, Hanson KM, Brewerton SC, Wheeler GN, Bodkin MJ, Evans DA, Bender A. Liggi S, et al. Among authors: drakakis g. Mol Inform. 2013 Dec;32(11-12):1009-24. doi: 10.1002/minf.201300102. Epub 2013 Oct 18. Mol Inform. 2013. PMID: 27481146

9

Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat.

Drakakis G, Wafford KA, Brewerton SC, Bodkin MJ, Evans DA, Bender A. Drakakis G, et al. ACS Chem Biol. 2017 Jun 16;12(6):1593-1602. doi: 10.1021/acschembio.7b00209. Epub 2017 May 1. ACS Chem Biol. 2017. PMID: 28414209 Free article.

10

Elucidating Compound Mechanism of Action and Predicting Cytotoxicity Using Machine Learning Approaches, Taking Prediction Confidence into Account.

Drakakis G, Cortés-Ciriano I, Alexander-Dann B, Bender A. Drakakis G, et al. Curr Protoc Chem Biol. 2019 Sep;11(3):e73. doi: 10.1002/cpch.73. Curr Protoc Chem Biol. 2019. PMID: 31483099

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