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A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nat Neurosci. 2022 Sep;25(9):1149-1162. doi: 10.1038/s41593-022-01131-4. Epub 2022 Aug 11.
Nat Neurosci. 2022.
PMID: 35953545
Free PMC article.
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis.
Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M.
Tian R, et al.
Nat Neurosci. 2021 Jul;24(7):1020-1034. doi: 10.1038/s41593-021-00862-0. Epub 2021 May 24.
Nat Neurosci. 2021.
PMID: 34031600
Free PMC article.
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Functional regulatory variants implicate distinct transcriptional networks in dementia.
Cooper YA, Teyssier N, Dräger NM, Guo Q, Davis JE, Sattler SM, Yang Z, Patel A, Wu S, Kosuri S, Coppola G, Kampmann M, Geschwind DH.
Cooper YA, et al. Among authors: drager nm.
Science. 2022 Aug 19;377(6608):eabi8654. doi: 10.1126/science.abi8654. Epub 2022 Aug 19.
Science. 2022.
PMID: 35981026
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Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.
de Majo M, Koontz M, Marsan E, Salinas N, Ramsey A, Kuo YM, Seo K, Li H, Dräger N, Leng K, Gonzales SL, Kurnellas M, Miyaoka Y, Klim JR, Kampmann M, Ward ME, Huang EJ, Ullian EM.
de Majo M, et al.
Stem Cell Reports. 2023 Mar 14;18(3):706-719. doi: 10.1016/j.stemcr.2023.01.012. Epub 2023 Feb 23.
Stem Cell Reports. 2023.
PMID: 36827976
Free PMC article.
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Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.
Hannan SB, Dräger NM, Rasse TM, Voigt A, Jahn TR.
Hannan SB, et al. Among authors: drager nm.
J Neurochem. 2016 Apr;137(1):12-25. doi: 10.1111/jnc.13532. Epub 2016 Feb 11.
J Neurochem. 2016.
PMID: 26756400
Free article.
Review.
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Bin1 directly remodels actin dynamics through its BAR domain.
Dräger NM, Nachman E, Winterhoff M, Brühmann S, Shah P, Katsinelos T, Boulant S, Teleman AA, Faix J, Jahn TR.
Dräger NM, et al.
EMBO Rep. 2017 Nov;18(11):2051-2066. doi: 10.15252/embr.201744137. Epub 2017 Sep 11.
EMBO Rep. 2017.
PMID: 28893863
Free PMC article.
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Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila.
Zhu JY, Hannan SB, Dräger NM, Vereshchagina N, Krahl AC, Fu Y, Elliott CJH, Han Z, Jahn TR, Rasse TM.
Zhu JY, et al. Among authors: drager nm.
Autophagy. 2021 Oct;17(10):3160-3174. doi: 10.1080/15548627.2020.1871211. Epub 2021 Jan 25.
Autophagy. 2021.
PMID: 33404278
Free PMC article.
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MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state.
You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D'Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E; Dominantly Inherited Alzheimer Network; Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM.
You SF, et al. Among authors: drager nm.
medRxiv [Preprint]. 2023 Feb 8:2023.02.06.23285545. doi: 10.1101/2023.02.06.23285545.
medRxiv. 2023.
PMID: 36798226
Free PMC article.
Preprint.
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