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Engineered phage with antibacterial CRISPR-Cas selectively reduce E. coli burden in mice.
Gencay YE, Jasinskytė D, Robert C, Semsey S, Martínez V, Petersen AØ, Brunner K, de Santiago Torio A, Salazar A, Turcu IC, Eriksen MK, Koval L, Takos A, Pascal R, Schou TS, Bayer L, Bryde T, Johansen KC, Bak EG, Smrekar F, Doyle TB, Satlin MJ, Gram A, Carvalho J, Jessen L, Hallström B, Hink J, Damholt B, Troy A, Grove M, Clube J, Grøndahl C, Haaber JK, van der Helm E, Zdravkovic M, Sommer MOA. Gencay YE, et al. Among authors: doyle tb. Nat Biotechnol. 2024 Feb;42(2):265-274. doi: 10.1038/s41587-023-01759-y. Epub 2023 May 4. Nat Biotechnol. 2024. PMID: 37142704 Free PMC article.
Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.
Free RB, Nilson AN, Boldizsar NM, Doyle TB, Rodriguiz RM, Pogorelov VM, Machino M, Lee KH, Bertz JW, Xu J, Lim HD, Dulcey AE, Mach RH, Woods JH, Lane JR, Shi L, Marugan JJ, Wetsel WC, Sibley DR. Free RB, et al. Among authors: doyle tb. ACS Pharmacol Transl Sci. 2022 Dec 30;6(1):151-170. doi: 10.1021/acsptsci.2c00202. eCollection 2023 Jan 13. ACS Pharmacol Transl Sci. 2022. PMID: 36654757 Free PMC article.
Prevalence of carbapenemase genes among carbapenem-nonsusceptible Enterobacterales collected in US hospitals in a five-year period and activity of ceftazidime/avibactam and comparator agents.
Castanheira M, Deshpande LM, Mendes RE, Doyle TB, Sader HS. Castanheira M, et al. Among authors: doyle tb. JAC Antimicrob Resist. 2022 Sep 30;4(5):dlac098. doi: 10.1093/jacamr/dlac098. eCollection 2022 Oct. JAC Antimicrob Resist. 2022. PMID: 36196444 Free PMC article.
The plethora of resistance mechanisms in Pseudomonas aeruginosa: transcriptome analysis reveals a potential role of lipopolysaccharide pathway proteins to novel β-lactam/β-lactamase inhibitor combinations.
Castanheira M, Doyle TB, Hubler CM, Collingsworth TD, DeVries S, Mendes RE. Castanheira M, et al. Among authors: doyle tb. J Glob Antimicrob Resist. 2022 Dec;31:72-79. doi: 10.1016/j.jgar.2022.07.021. Epub 2022 Aug 3. J Glob Antimicrob Resist. 2022. PMID: 35931381 Free article.
42 results