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Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.
Trzaskalski NA, Vulesevic B, Nguyen MA, Jeraj N, Fadzeyeva E, Morrow NM, Locatelli CA, Travis N, Hanson AA, Nunes JR, O'Dwyer C, van der Veen JN, Lorenzen-Schmidt I, Seymour R, Pulente SM, Clément AC, Crawley AM, Jacobs RL, Doyle MA, Cooper CL, Kim KH, Fullerton MD, Mulvihill EE. Trzaskalski NA, et al. Among authors: doyle ma. JCI Insight. 2023 Jan 24;8(2):e154314. doi: 10.1172/jci.insight.154314. JCI Insight. 2023. PMID: 36472923 Free PMC article.
Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress.
Fadzeyeva E, Locatelli CAA, Trzaskalski NA, Nguyen MA, Capozzi ME, Vulesevic B, Morrow NM, Ghorbani P, Hanson AA, Lorenzen-Schmidt I, Doyle MA, Seymour R, Varin EM, Fullerton MD, Campbell JE, Mulvihill EE. Fadzeyeva E, et al. Among authors: doyle ma. iScience. 2023 Apr 26;26(5):106748. doi: 10.1016/j.isci.2023.106748. eCollection 2023 May 19. iScience. 2023. PMID: 37216093 Free PMC article.
119 results