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Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.
Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ. Xu J, et al. Among authors: dowsey aw. Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524. Sci Rep. 2016. PMID: 27276998 Free PMC article.
Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.
Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Aitken JF, et al. Among authors: dowsey aw. Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16. Biochem Biophys Res Commun. 2017. PMID: 27865831
Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.
Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips AR, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJ. Aitken JF, et al. Among authors: dowsey aw. Data Brief. 2016 Nov 29;10:298-303. doi: 10.1016/j.dib.2016.11.077. eCollection 2017 Feb. Data Brief. 2016. PMID: 27995166 Free PMC article.
Regional protein expression in human Alzheimer's brain correlates with disease severity.
Xu J, Patassini S, Rustogi N, Riba-Garcia I, Hale BD, Phillips AM, Waldvogel H, Haines R, Bradbury P, Stevens A, Faull RLM, Dowsey AW, Cooper GJS, Unwin RD. Xu J, et al. Among authors: dowsey aw. Commun Biol. 2019 Feb 4;2:43. doi: 10.1038/s42003-018-0254-9. eCollection 2019. Commun Biol. 2019. PMID: 30729181 Free PMC article.
Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26.
Mcharg S, Booth L, Perveen R, Riba Garcia I, Brace N, Bayatti N, Sergouniotis PI, Phillips AM, Day AJ, Black GCM, Clark SJ, Dowsey AW, Unwin RD, Bishop PN. Mcharg S, et al. Among authors: dowsey aw. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2118510119. doi: 10.1073/pnas.2118510119. Epub 2022 May 13. Proc Natl Acad Sci U S A. 2022. PMID: 35561216 Free PMC article.
36 results