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Identification of diurnal rhythmic blood markers in bronchial asthma.
Krakowiak K, Maidstone RJ, Chakraborty A, Kendall AC, Nicolaou A, Downton P, Cristian AD, Singh D, Loudon ASI, Ray DW, Durrington HJ. Krakowiak K, et al. Among authors: downton p. ERJ Open Res. 2023 Jul 3;9(4):00161-2023. doi: 10.1183/23120541.00161-2023. eCollection 2023 Jul. ERJ Open Res. 2023. PMID: 37404842 Free PMC article.
Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism.
Downton P, Sanna F, Maidstone R, Poolman TM, Hayter EA, Dickson SH, Ciccone NA, Early JO, Adamson A, Spiller DG, Simpkins DA, Baxter M, Fischer R, Rattray M, Loudon ASI, Gibbs JE, Bechtold DA, Ray DW. Downton P, et al. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2112781119. doi: 10.1073/pnas.2112781119. Epub 2022 Apr 28. Proc Natl Acad Sci U S A. 2022. PMID: 35482925 Free PMC article.
Adipocyte NR1D1 dictates adipose tissue expansion during obesity.
Hunter AL, Pelekanou CE, Barron NJ, Northeast RC, Grudzien M, Adamson AD, Downton P, Cornfield T, Cunningham PS, Billaud JN, Hodson L, Loudon AS, Unwin RD, Iqbal M, Ray DW, Bechtold DA. Hunter AL, et al. Among authors: downton p. Elife. 2021 Aug 5;10:e63324. doi: 10.7554/eLife.63324. Elife. 2021. PMID: 34350828 Free PMC article.
Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism.
Hunter AL, Pelekanou CE, Adamson A, Downton P, Barron NJ, Cornfield T, Poolman TM, Humphreys N, Cunningham PS, Hodson L, Loudon ASI, Iqbal M, Bechtold DA, Ray DW. Hunter AL, et al. Among authors: downton p. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25869-25879. doi: 10.1073/pnas.2005330117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989157 Free PMC article.
Circadian rhythms in adaptive immunity.
Downton P, Early JO, Gibbs JE. Downton P, et al. Immunology. 2020 Dec;161(4):268-277. doi: 10.1111/imm.13167. Epub 2020 Jan 19. Immunology. 2020. PMID: 31837013 Free PMC article. Review.
Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation.
Bagnall J, Boddington C, England H, Brignall R, Downton P, Alsoufi Z, Boyd J, Rowe W, Bennett A, Walker C, Adamson A, Patel NMX, O'Cualain R, Schmidt L, Spiller DG, Jackson DA, Müller W, Muldoon M, White MRH, Paszek P. Bagnall J, et al. Among authors: downton p. Sci Signal. 2018 Jul 24;11(540):eaaf3998. doi: 10.1126/scisignal.aaf3998. Sci Signal. 2018. PMID: 30042130
Temperature regulates NF-κB dynamics and function through timing of A20 transcription.
Harper CV, Woodcock DJ, Lam C, Garcia-Albornoz M, Adamson A, Ashall L, Rowe W, Downton P, Schmidt L, West S, Spiller DG, Rand DA, White MRH. Harper CV, et al. Among authors: downton p. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5243-E5249. doi: 10.1073/pnas.1803609115. Epub 2018 May 14. Proc Natl Acad Sci U S A. 2018. PMID: 29760065 Free PMC article.
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