Downs TR - Search Results

1

Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Pfuhler S, Pirow R, Downs TR, Haase A, Hewitt N, Luch A, Merkel M, Petrick C, Said A, Schäfer-Korting M, Reisinger K. Pfuhler S, et al. Among authors: downs tr. Mutagenesis. 2021 Apr 28;36(1):19-35. doi: 10.1093/mutage/geaa009. Mutagenesis. 2021. PMID: 32152633 Free PMC article.

2

Comet assay in reconstructed 3D human epidermal skin models--investigation of intra- and inter-laboratory reproducibility with coded chemicals.

Reus AA, Reisinger K, Downs TR, Carr GJ, Zeller A, Corvi R, Krul CA, Pfuhler S. Reus AA, et al. Among authors: downs tr. Mutagenesis. 2013 Nov;28(6):709-20. doi: 10.1093/mutage/get051. Mutagenesis. 2013. PMID: 24150594 Free PMC article.

3

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

Reisinger K, Blatz V, Brinkmann J, Downs TR, Fischer A, Henkler F, Hoffmann S, Krul C, Liebsch M, Luch A, Pirow R, Reus AA, Schulz M, Pfuhler S. Reisinger K, et al. Among authors: downs tr. Mutat Res Genet Toxicol Environ Mutagen. 2018 Mar;827:27-41. doi: 10.1016/j.mrgentox.2018.01.003. Epub 2018 Jan 10. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29502735 Free article.

4

Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models.

Downs TR, Arlt VM, Barnett BC, Posgai R, Pfuhler S. Downs TR, et al. Mutagenesis. 2021 Apr 28;36(1):63-74. doi: 10.1093/mutage/gez044. Mutagenesis. 2021. PMID: 31816077 Free PMC article.

5

Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Pfuhler S, Downs TR, Hewitt NJ, Hoffmann S, Mun GC, Ouedraogo G, Roy S, Curren RD, Aardema MJ. Pfuhler S, et al. Among authors: downs tr. Mutagenesis. 2021 Apr 28;36(1):1-17. doi: 10.1093/mutage/geaa035. Mutagenesis. 2021. PMID: 33544138 Free PMC article.

6

Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis.

Pfuhler S, Downs TR, Allemang AJ, Shan Y, Crosby ME. Pfuhler S, et al. Among authors: downs tr. Mutagenesis. 2017 Jan;32(1):5-12. doi: 10.1093/mutage/gew064. Epub 2016 Nov 17. Mutagenesis. 2017. PMID: 27864332

7

Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not.

Downs TR, Crosby ME, Hu T, Kumar S, Sullivan A, Sarlo K, Reeder B, Lynch M, Wagner M, Mills T, Pfuhler S. Downs TR, et al. Mutat Res. 2012 Jun 14;745(1-2):38-50. doi: 10.1016/j.mrgentox.2012.03.012. Epub 2012 Apr 6. Mutat Res. 2012. PMID: 22504169

8

Mitotic inhibition and aneuploidy induction by naturally occurring and synthetic estrogens in Chinese hamster cells in vitro.

Wheeler WJ, Cherry LM, Downs T, Hsu TC. Wheeler WJ, et al. Mutat Res. 1986 Jul;171(1):31-41. doi: 10.1016/0165-1218(86)90006-6. Mutat Res. 1986. PMID: 3724781

9

Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction.

Gratzke C, Streng T, Stief CG, Alroy I, Limberg BJ, Downs TR, Rosenbaum JS, Hedlund P, Andersson KE. Gratzke C, et al. Among authors: downs tr. J Urol. 2011 Feb;185(2):731-6. doi: 10.1016/j.juro.2010.09.080. Epub 2010 Dec 18. J Urol. 2011. PMID: 21168864

10

Urothelial beta-3 adrenergic receptors in the rat bladder.

Kullmann FA, Downs TR, Artim DE, Limberg BJ, Shah M, Contract D, de Groat WC, Rosenbaum JS. Kullmann FA, et al. Among authors: downs tr. Neurourol Urodyn. 2011 Jan;30(1):144-50. doi: 10.1002/nau.20965. Neurourol Urodyn. 2011. PMID: 21046653 Free PMC article.

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