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A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, O'Brien J, Ní Eidhin D, O'Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O'Neill LA, Kelleher D, Loscher CE. Ryan A, et al. Among authors: dowling jk. PLoS Pathog. 2011 Jun;7(6):e1002076. doi: 10.1371/journal.ppat.1002076. Epub 2011 Jun 30. PLoS Pathog. 2011. PMID: 21738466 Free PMC article.
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE. Dowling JK, et al. Nat Commun. 2021 Mar 5;12(1):1460. doi: 10.1038/s41467-021-21617-2. Nat Commun. 2021. PMID: 33674584 Free PMC article.
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair.
Hibbitts AJ, Kočí Z, Kneafsey S, Matsiko A, Žilić L, Dervan A, Hinton P, Chen G, Cavanagh B, Dowling JK, McCoy CE, Buckley CT, Archibald SJ, O'Brien FJ. Hibbitts AJ, et al. Among authors: dowling jk. Matrix Biol. 2022 Feb;106:34-57. doi: 10.1016/j.matbio.2022.01.002. Epub 2022 Jan 13. Matrix Biol. 2022. PMID: 35032612 Free article.
Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers.
Fitzsimons S, Muñoz-San Martín M, Nally F, Dillon E, Fashina IA, Strowitzki MJ, Ramió-Torrentà L, Dowling JK, De Santi C, McCoy CE. Fitzsimons S, et al. Among authors: dowling jk. Mol Ther Nucleic Acids. 2023 Aug 22;33:941-959. doi: 10.1016/j.omtn.2023.08.023. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37701067 Free PMC article.
Biochemical regulation of the inflammasome.
Dowling JK, O'Neill LA. Dowling JK, et al. Crit Rev Biochem Mol Biol. 2012 Sep;47(5):424-43. doi: 10.3109/10409238.2012.694844. Epub 2012 Jun 11. Crit Rev Biochem Mol Biol. 2012. PMID: 22681257 Review.
26 results