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Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.
Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y. Zhang Y, et al. Among authors: dowhan w. J Clin Invest. 2014 Jun;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837436 Free PMC article.
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia.
Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y. Sun K, et al. Among authors: dowhan w. Nat Commun. 2016 Jul 15;7:12086. doi: 10.1038/ncomms12086. Nat Commun. 2016. PMID: 27417539 Free PMC article.
Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y. Sun K, et al. Among authors: dowhan w. Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8. Sci Rep. 2017. PMID: 29127281 Free PMC article.
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Song A, et al. Among authors: dowhan w. Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108. Nat Commun. 2017. PMID: 28169986 Free PMC article.
Lipid-dependent membrane protein topogenesis.
Dowhan W, Bogdanov M. Dowhan W, et al. Annu Rev Biochem. 2009;78:515-40. doi: 10.1146/annurev.biochem.77.060806.091251. Annu Rev Biochem. 2009. PMID: 19489728 Free PMC article. Review.
170 results