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TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis.
Gauthier T, Yao C, Dowdy T, Jin W, Lim YJ, Patiño LC, Liu N, Ohlemacher SI, Bynum A, Kazmi R, Bewley CA, Mitrovic M, Martin D, Morell RJ, Eckhaus M, Larion M, Tussiwand R, O'Shea JJ, Chen W. Gauthier T, et al. Among authors: dowdy t. Sci Signal. 2023 Aug 8;16(797):eade0385. doi: 10.1126/scisignal.ade0385. Epub 2023 Aug 8. Sci Signal. 2023. PMID: 37552767
Targeting the Sphingolipid Rheostat in Gliomas.
Zaibaq F, Dowdy T, Larion M. Zaibaq F, et al. Among authors: dowdy t. Int J Mol Sci. 2022 Aug 17;23(16):9255. doi: 10.3390/ijms23169255. Int J Mol Sci. 2022. PMID: 36012521 Free PMC article. Review.
Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies.
Ratnam NM, Sonnemann HM, Frederico SC, Chen H, Hutchinson MND, Dowdy T, Reid CM, Jung J, Zhang W, Song H, Zhang M, Davis D, Larion M, Giles AJ, Gilbert MR. Ratnam NM, et al. Among authors: dowdy t. Front Oncol. 2021 Jul 15;11:719091. doi: 10.3389/fonc.2021.719091. eCollection 2021. Front Oncol. 2021. PMID: 34336705 Free PMC article.
Cysteine is a limiting factor for glioma proliferation and survival.
Ruiz-Rodado V, Dowdy T, Lita A, Kramp T, Zhang M, Jung J, Dios-Esponera A, Zhang L, Herold-Mende CC, Camphausen K, Gilbert MR, Larion M. Ruiz-Rodado V, et al. Among authors: dowdy t. Mol Oncol. 2022 May;16(9):1777-1794. doi: 10.1002/1878-0261.13148. Epub 2022 Jan 6. Mol Oncol. 2022. PMID: 34856072 Free PMC article.
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J 3rd, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott GM, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM. Yeung C, et al. Among authors: dowdy t. Cancer Res. 2019 Oct 1;79(19):5060-5073. doi: 10.1158/0008-5472.CAN-19-0217. Epub 2019 Aug 20. Cancer Res. 2019. PMID: 31431459 Free PMC article.
22 results