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Structure-guided microbial targeting of antistaphylococcal prodrugs.
Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet PJ, Muller FL, Jez JM, Odom John AR. Miller JJ, et al. Among authors: dowd cs. Elife. 2021 Jul 19;10:e66657. doi: 10.7554/eLife.66657. Elife. 2021. PMID: 34279224 Free PMC article.
Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.
San Jose G, Jackson ER, Haymond A, Johny C, Edwards RL, Wang X, Brothers RC, Edelstein EK, Odom AR, Boshoff HI, Couch RD, Dowd CS. San Jose G, et al. Among authors: dowd cs. ACS Infect Dis. 2016 Dec 9;2(12):923-935. doi: 10.1021/acsinfecdis.6b00125. Epub 2016 Oct 12. ACS Infect Dis. 2016. PMID: 27676224 Free PMC article.
MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.
Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, John ARO. Edwards RL, et al. Among authors: dowd cs. Sci Rep. 2017 Aug 21;7(1):8400. doi: 10.1038/s41598-017-07159-y. Sci Rep. 2017. PMID: 28827774 Free PMC article.
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: dowd cs. J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24. J Med Chem. 2018. PMID: 30192536 Free PMC article.
Phosphonate prodrugs: an overview and recent advances.
Heidel KM, Dowd CS. Heidel KM, et al. Among authors: dowd cs. Future Med Chem. 2019 Jul;11(13):1625-1643. doi: 10.4155/fmc-2018-0591. Future Med Chem. 2019. PMID: 31469328 Free PMC article. Review.
Potent, specific MEPicides for treatment of zoonotic staphylococci.
Edwards RL, Heueck I, Lee SG, Shah IT, Miller JJ, Jezewski AJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Osbourn DM, Burnham CD, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom John AR. Edwards RL, et al. Among authors: dowd cs. PLoS Pathog. 2020 Jun 4;16(6):e1007806. doi: 10.1371/journal.ppat.1007806. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32497104 Free PMC article.
Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB.
Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Mikati MO, et al. Among authors: dowd cs. ACS Infect Dis. 2020 Nov 13;6(11):3064-3075. doi: 10.1021/acsinfecdis.0c00582. Epub 2020 Oct 29. ACS Infect Dis. 2020. PMID: 33118347 Free PMC article.
Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs.
Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet P, Muller FL, Jez J, Odom John AR. Miller JJ, et al. Among authors: dowd cs. Elife. 2021 Nov 25;10:e75743. doi: 10.7554/eLife.75743. Elife. 2021. PMID: 34821554 Free PMC article.
MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase.
Wang X, Edwards RL, Ball HS, Heidel KM, Brothers RC, Johnson C, Haymond A, Girma M, Dailey A, Roma JS, Boshoff HI, Osbourn DM, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: dowd cs. ACS Infect Dis. 2023 Jul 14;9(7):1387-1395. doi: 10.1021/acsinfecdis.3c00132. Epub 2023 Jun 13. ACS Infect Dis. 2023. PMID: 37310810
49 results