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Caspofungin: the first in a new class of antifungal agents.
Kartsonis NA, Nielsen J, Douglas CM. Kartsonis NA, et al. Among authors: douglas cm. Drug Resist Updat. 2003 Aug;6(4):197-218. doi: 10.1016/s1368-7646(03)00064-5. Drug Resist Updat. 2003. PMID: 12962685 Review.
Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate.
Bowman JC, Abruzzo GK, Anderson JW, Flattery AM, Gill CJ, Pikounis VB, Schmatz DM, Liberator PA, Douglas CM. Bowman JC, et al. Among authors: douglas cm. Antimicrob Agents Chemother. 2001 Dec;45(12):3474-81. doi: 10.1128/AAC.45.12.3474-3481.2001. Antimicrob Agents Chemother. 2001. PMID: 11709327 Free PMC article.
Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.
Onishi J, Meinz M, Thompson J, Curotto J, Dreikorn S, Rosenbach M, Douglas C, Abruzzo G, Flattery A, Kong L, Cabello A, Vicente F, Pelaez F, Diez MT, Martin I, Bills G, Giacobbe R, Dombrowski A, Schwartz R, Morris S, Harris G, Tsipouras A, Wilson K, Kurtz MB. Onishi J, et al. Antimicrob Agents Chemother. 2000 Feb;44(2):368-77. doi: 10.1128/AAC.44.2.368-377.2000. Antimicrob Agents Chemother. 2000. PMID: 10639364 Free PMC article.
Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis.
Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE Jr, Douglas CM. Ibrahim AS, et al. Among authors: douglas cm. Antimicrob Agents Chemother. 2005 Feb;49(2):721-7. doi: 10.1128/AAC.49.2.721-727.2005. Antimicrob Agents Chemother. 2005. PMID: 15673756 Free PMC article.
123 results