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In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives.
Astuto MC, Di Nicola MR, Tarazona JV, Rortais A, Devos Y, Liem AKD, Kass GEN, Bastaki M, Schoonjans R, Maggiore A, Charles S, Ratier A, Lopes C, Gestin O, Robinson T, Williams A, Kramer N, Carnesecchi E, Dorne JCM. Astuto MC, et al. Among authors: dorne jcm. Methods Mol Biol. 2022;2425:589-636. doi: 10.1007/978-1-0716-1960-5_23. Methods Mol Biol. 2022. PMID: 35188648
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.
Paini A, Leonard JA, Joossens E, Bessems JGM, Desalegn A, Dorne JL, Gosling JP, Heringa MB, Klaric M, Kliment T, Kramer NI, Loizou G, Louisse J, Lumen A, Madden JC, Patterson EA, Proença S, Punt A, Setzer RW, Suciu N, Troutman J, Yoon M, Worth A, Tan YM. Paini A, et al. Comput Toxicol. 2019 Feb;9:61-72. doi: 10.1016/j.comtox.2018.11.002. Comput Toxicol. 2019. PMID: 31008414 Free PMC article. Review.
A regression-based QSAR-model to predict acute toxicity of aromatic chemicals in tadpoles of the Japanese brown frog (Rana japonica): Calibration, validation, and future developments to support risk assessment of chemicals in amphibians.
Toropov AA, Di Nicola MR, Toropova AP, Roncaglioni A, Carnesecchi E, Kramer NI, Williams AJ, Ortiz-Santaliestra ME, Benfenati E, Dorne JCM. Toropov AA, et al. Among authors: dorne jcm. Sci Total Environ. 2022 Jul 15;830:154795. doi: 10.1016/j.scitotenv.2022.154795. Epub 2022 Mar 25. Sci Total Environ. 2022. PMID: 35341855 Free PMC article.
Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance.
Gouliarmou V, Lostia AM, Coecke S, Bernasconi C, Bessems J, Dorne JL, Ferguson S, Testai E, Remy UG, Brian Houston J, Monshouwer M, Nong A, Pelkonen O, Morath S, Wetmore BA, Worth A, Zanelli U, Zorzoli MC, Whelan M. Gouliarmou V, et al. Toxicol In Vitro. 2018 Dec;53:233-244. doi: 10.1016/j.tiv.2018.08.004. Epub 2018 Aug 9. Toxicol In Vitro. 2018. PMID: 30099088 Free PMC article.
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization.
Paul Friedman K, Gagne M, Loo LH, Karamertzanis P, Netzeva T, Sobanski T, Franzosa JA, Richard AM, Lougee RR, Gissi A, Lee JJ, Angrish M, Dorne JL, Foster S, Raffaele K, Bahadori T, Gwinn MR, Lambert J, Whelan M, Rasenberg M, Barton-Maclaren T, Thomas RS. Paul Friedman K, et al. Toxicol Sci. 2020 Jan 1;173(1):202-225. doi: 10.1093/toxsci/kfz201. Toxicol Sci. 2020. PMID: 31532525 Free PMC article.
54 results