Donnelly D - Search Results

1

New variants and in silico analyses in GRK1 associated Oguchi disease.

Poulter JA, Gravett MSC, Taylor RL, Fujinami K, De Zaeytijd J, Bellingham J, Rehman AU, Hayashi T, Kondo M, Rehman A, Ansar M, Donnelly D, Toomes C, Ali M; UK Inherited Retinal Disease Consortium, Genomics England Research Consortium; De Baere E, Leroy BP, Davies NP, Henderson RH, Webster AR, Rivolta C, Zeitz C, Mahroo OA, Arno G, Black GCM, McKibbin M, Harris SA, Khan KN, Inglehearn CF. Poulter JA, et al. Among authors: donnelly d. Hum Mutat. 2021 Feb;42(2):164-176. doi: 10.1002/humu.24140. Epub 2020 Nov 30. Hum Mutat. 2021. PMID: 33252155 Free PMC article.

2

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.

Mann RJ, Nasr NE, Sinfield JK, Paci E, Donnelly D. Mann RJ, et al. Among authors: donnelly d. Br J Pharmacol. 2010 Aug;160(8):1973-84. doi: 10.1111/j.1476-5381.2010.00834.x. Br J Pharmacol. 2010. PMID: 20649595 Free PMC article.

3

The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge.

López de Maturana R, Donnelly D. López de Maturana R, et al. Among authors: donnelly d. FEBS Lett. 2002 Oct 23;530(1-3):244-8. doi: 10.1016/s0014-5793(02)03492-0. FEBS Lett. 2002. PMID: 12387900 Free article.

4

Peptide binding at the GLP-1 receptor.

Mann R, Nasr N, Hadden D, Sinfield J, Abidi F, Al-Sabah S, de Maturana RL, Treece-Birch J, Willshaw A, Donnelly D. Mann R, et al. Among authors: donnelly d. Biochem Soc Trans. 2007 Aug;35(Pt 4):713-6. doi: 10.1042/BST0350713. Biochem Soc Trans. 2007. PMID: 17635131 Review.

5

A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics.

Gómez Santiago C, Paci E, Donnelly D. Gómez Santiago C, et al. Among authors: donnelly d. Biochem Biophys Res Commun. 2018 Mar 29;498(2):359-365. doi: 10.1016/j.bbrc.2018.01.110. Epub 2018 Feb 12. Biochem Biophys Res Commun. 2018. PMID: 29397068 Free article.

6

Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.

Graaf Cd, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn JM, Liao J, Fletcher MM, Yang D, Brown AJ, Zhou C, Deng J, Wang MW. Graaf Cd, et al. Among authors: donnelly d. Pharmacol Rev. 2016 Oct;68(4):954-1013. doi: 10.1124/pr.115.011395. Pharmacol Rev. 2016. PMID: 27630114 Free PMC article. Review.

7

Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.

Mann R, Wigglesworth MJ, Donnelly D. Mann R, et al. Among authors: donnelly d. Mol Pharmacol. 2008 Sep;74(3):605-13. doi: 10.1124/mol.108.048017. Epub 2008 Jun 6. Mol Pharmacol. 2008. PMID: 18539702

8

Conformational induction is the key process for activation of the AT1 receptor.

Ellis J, Warburton P, Donnelly D, Balmforth AJ. Ellis J, et al. Among authors: donnelly d. Biochem Pharmacol. 2006 Feb 14;71(4):464-71. doi: 10.1016/j.bcp.2005.11.011. Epub 2005 Dec 15. Biochem Pharmacol. 2006. PMID: 16343447

9

The relationship between the agonist-induced activation and desensitization of the human tachykinin NK2 receptor expressed in Xenopus oocytes.

Maudsley S, Gent JP, Findlay JB, Donnelly D. Maudsley S, et al. Among authors: donnelly d. Br J Pharmacol. 1998 Jun;124(4):675-84. doi: 10.1038/sj.bjp.0701889. Br J Pharmacol. 1998. PMID: 9690859 Free PMC article.

10

Pharmacophore model of the quercetin binding site of the SIRT6 protein.

Ravichandran S, Singh N, Donnelly D, Migliore M, Johnson P, Fishwick C, Luke BT, Martin B, Maudsley S, Fugmann SD, Moaddel R. Ravichandran S, et al. Among authors: donnelly d. J Mol Graph Model. 2014 Apr;49:38-46. doi: 10.1016/j.jmgm.2014.01.004. Epub 2014 Jan 20. J Mol Graph Model. 2014. PMID: 24491483 Free PMC article.

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