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Time to evolve: predicting engineered T cell-associated toxicity with next-generation models.
Donnadieu E, Luu M, Alb M, Anliker B, Arcangeli S, Bonini C, De Angelis B, Choudhary R, Espie D, Galy A, Holland C, Ivics Z, Kantari-Mimoun C, Kersten MJ, Köhl U, Kuhn C, Laugel B, Locatelli F, Marchiq I, Markman J, Moresco MA, Morris E, Negre H, Quintarelli C, Rade M, Reiche K, Renner M, Ruggiero E, Sanges C, Stauss H, Themeli M, Van den Brulle J, Hudecek M, Casucci M. Donnadieu E, et al. J Immunother Cancer. 2022 May;10(5):e003486. doi: 10.1136/jitc-2021-003486. J Immunother Cancer. 2022. PMID: 35577500 Free PMC article. Review.
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1.
Kantari-Mimoun C, Barrin S, Vimeux L, Haghiri S, Gervais C, Joaquina S, Mittelstaet J, Mockel-Tenbrinck N, Kinkhabwala A, Damotte D, Lupo A, Sibony M, Alifano M, Dondi E, Bercovici N, Trautmann A, Kaiser AD, Donnadieu E. Kantari-Mimoun C, et al. Among authors: donnadieu e. Cancer Immunol Res. 2021 Dec;9(12):1425-1438. doi: 10.1158/2326-6066.CIR-20-0837. Epub 2021 Oct 22. Cancer Immunol Res. 2021. PMID: 34686489
Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?
Guedan S, Luu M, Ammar D, Barbao P, Bonini C, Bousso P, Buchholz CJ, Casucci M, De Angelis B, Donnadieu E, Espie D, Greco B, Groen R, Huppa JB, Kantari-Mimoun C, Laugel B, Mantock M, Markman JL, Morris E, Quintarelli C, Rade M, Reiche K, Rodriguez-Garcia A, Rodriguez-Madoz JR, Ruggiero E, Themeli M, Hudecek M, Marchiq I. Guedan S, et al. Among authors: donnadieu e. J Immunother Cancer. 2022 May;10(5):e003487. doi: 10.1136/jitc-2021-003487. J Immunother Cancer. 2022. PMID: 35577501 Free PMC article. Review.
CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models.
Seif M, Kakoschke TK, Ebel F, Bellet MM, Trinks N, Renga G, Pariano M, Romani L, Tappe B, Espie D, Donnadieu E, Hünniger K, Häder A, Sauer M, Damotte D, Alifano M, White PL, Backx M, Nerreter T, Machwirth M, Kurzai O, Prommersberger S, Einsele H, Hudecek M, Löffler J. Seif M, et al. Among authors: donnadieu e. Sci Transl Med. 2022 Sep 28;14(664):eabh1209. doi: 10.1126/scitranslmed.abh1209. Epub 2022 Sep 28. Sci Transl Med. 2022. PMID: 36170447
New insights into CAR T cell-mediated killing of tumor cells.
Espie D, Donnadieu E. Espie D, et al. Among authors: donnadieu e. Front Immunol. 2022 Sep 15;13:1016208. doi: 10.3389/fimmu.2022.1016208. eCollection 2022. Front Immunol. 2022. PMID: 36189315 Free PMC article. Review.
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.
Peranzoni E, Lemoine J, Vimeux L, Feuillet V, Barrin S, Kantari-Mimoun C, Bercovici N, Guérin M, Biton J, Ouakrim H, Régnier F, Lupo A, Alifano M, Damotte D, Donnadieu E. Peranzoni E, et al. Among authors: donnadieu e. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4041-E4050. doi: 10.1073/pnas.1720948115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632196 Free PMC article.
Obstacles to T cell migration in the tumor microenvironment.
Nicolas-Boluda A, Donnadieu E. Nicolas-Boluda A, et al. Among authors: donnadieu e. Comp Immunol Microbiol Infect Dis. 2019 Apr;63:22-30. doi: 10.1016/j.cimid.2018.12.006. Epub 2018 Dec 27. Comp Immunol Microbiol Infect Dis. 2019. PMID: 30961814
83 results