Dong Y - Search Results

1

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, Papastogiannidis P, Scheurer C, Shackleford DM, Sriraghavan K, Stingelin L, Tang Y, Urwyler H, Wang X, White KL, Wittlin S, Zhou L, Vennerstrom JL. Charman SA, et al. Among authors: dong y. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5. doi: 10.1073/pnas.1015762108. Epub 2011 Feb 7. Proc Natl Acad Sci U S A. 2011. PMID: 21300861 Free PMC article.

2

Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.

Dong Y, Matile H, Chollet J, Kaminsky R, Wood JK, Vennerstrom JL. Dong Y, et al. J Med Chem. 1999 Apr 22;42(8):1477-80. doi: 10.1021/jm980698f. J Med Chem. 1999. PMID: 10212135

3

Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.

Vennerstrom JL, Dong Y, Andersen SL, Ager AL Jr, Fu H, Miller RE, Wesche DL, Kyle DE, Gerena L, Walters SM, Wood JK, Edwards G, Holme AD, McLean WG, Milhous WK. Vennerstrom JL, et al. Among authors: dong y. J Med Chem. 2000 Jul 13;43(14):2753-8. doi: 10.1021/jm0000766. J Med Chem. 2000. PMID: 10893313

4

Mechanisms of in situ activation for peroxidic antimalarials.

Dong Y, Vennerstrom JL. Dong Y, et al. Redox Rep. 2003;8(5):284-8. doi: 10.1179/135100003225002989. Redox Rep. 2003. PMID: 14962366 Review.

5

Synthetic peroxides as antimalarials.

Tang Y, Dong Y, Vennerstrom JL. Tang Y, et al. Among authors: dong y. Med Res Rev. 2004 Jul;24(4):425-48. doi: 10.1002/med.10066. Med Res Rev. 2004. PMID: 15170591 Review.

6

Identification of an antimalarial synthetic trioxolane drug development candidate.

Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN. Vennerstrom JL, et al. Among authors: dong y. Nature. 2004 Aug 19;430(7002):900-4. doi: 10.1038/nature02779. Nature. 2004. PMID: 15318224 Free article.

7

Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions.

Tang Y, Dong Y, Karle JM, DiTusa CA, Vennerstrom JL. Tang Y, et al. Among authors: dong y. J Org Chem. 2004 Sep 17;69(19):6470-3. doi: 10.1021/jo040171c. J Org Chem. 2004. PMID: 15357611

8

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

Tang Y, Dong Y, Wang X, Sriraghavan K, Wood JK, Vennerstrom JL. Tang Y, et al. Among authors: dong y. J Org Chem. 2005 Jun 24;70(13):5103-10. doi: 10.1021/jo050385+. J Org Chem. 2005. PMID: 15960511

9

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL. Dong Y, et al. J Med Chem. 2005 Jul 28;48(15):4953-61. doi: 10.1021/jm049040u. J Med Chem. 2005. PMID: 16033274

10

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.

Perry CS, Charman SA, Prankerd RJ, Chiu FC, Dong Y, Vennerstrom JL, Charman WN. Perry CS, et al. Among authors: dong y. J Pharm Sci. 2006 Apr;95(4):737-47. doi: 10.1002/jps.20568. J Pharm Sci. 2006. PMID: 16435367

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