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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
Tan Y, Mosallanejad K, Zhang Q, O'Brien S, Clements M, Perper S, Wilson S, Chaulagain S, Wang J, Abdalla M, Al-Saidi H, Butt D, Clabbers A, Ofori K, Dillon B, Harvey B, Memmott J, Negron C, Winarta D, Tan C, Biswas A, Dong F, Morales-Tirado V, Lu X, Singh G, White M, Ashley S, Knight H, Westmoreland S, Phillips L, Carr T, Reinke-Breen L, Singh R, Xu J, Wu K, Rinaldi L, Stoll B, He YD, Hazelwood L, Karman J, McCluskey A, Stine W, Correia I, Gauld S, Levesque MC, Veldman G, Hubeau C, Radstake T, Sadhukhan R, Fiebiger E. Tan Y, et al. Among authors: dong f. Front Immunol. 2024 Feb 22;15:1293883. doi: 10.3389/fimmu.2024.1293883. eCollection 2024. Front Immunol. 2024. PMID: 38455057 Free PMC article.
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
Pai CS, Simons DM, Lu X, Evans M, Wei J, Wang YH, Chen M, Huang J, Park C, Chang A, Wang J, Westmoreland S, Beam C, Banach D, Bowley D, Dong F, Seagal J, Ritacco W, Richardson PL, Mitra S, Lynch G, Bousquet P, Mankovich J, Kingsbury G, Fong L. Pai CS, et al. Among authors: dong f. J Clin Invest. 2019 Jan 2;129(1):349-363. doi: 10.1172/JCI123391. Epub 2018 Dec 10. J Clin Invest. 2019. PMID: 30530991 Free PMC article.
Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration.
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris MC, Clabbers A, Dong F, Shen J, Hackett SF, Touw DS, Bixby J, Zhong S, Benatuil L, Bose S, Grinnell C, Preston GM, Iyer R, Sadhukhan R, Marchie S, Overmeyer G, Ghayur T, van Riet DA, Tang S, Campochario PA, Gu J. Ding K, et al. Among authors: dong f. MAbs. 2017 Feb/Mar;9(2):269-284. doi: 10.1080/19420862.2016.1268305. MAbs. 2017. PMID: 27929753 Free PMC article.
ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies.
Chervin AS, Stone JD, Konieczna I, Calabrese KM, Wang N, Haribhai D, Dong F, White MK, Rodriguez LE, Bukofzer GT, Ellis PA, Cosgrove C, Hecquet C, Clarin JD, Palma JP, Reilly EB. Chervin AS, et al. Among authors: dong f. Mol Cancer Ther. 2023 Aug 1;22(8):903-912. doi: 10.1158/1535-7163.MCT-22-0770. Mol Cancer Ther. 2023. PMID: 37294945
Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig.
Bardwell PD, Staron MM, Liu J, Tao Q, Scesney S, Bukofzer G, Rodriguez LE, Choi CH, Wang J, Chang Q, Dong F, Donawho C, Wang J, Grinnell CM, Tarcsa E, Hutchins C, Ghayur T, Gu J. Bardwell PD, et al. Among authors: dong f. Protein Cell. 2018 Jan;9(1):121-129. doi: 10.1007/s13238-017-0429-z. Epub 2017 Jun 5. Protein Cell. 2018. PMID: 28585177 Free PMC article.
Recent advancements in DVD-Ig based therapeutic development.
Dong F, Ghayur T. Dong F, et al. Drug Discov Today Technol. 2019 Dec;34:1-7. doi: 10.1016/j.ddtec.2020.10.002. Epub 2020 Nov 20. Drug Discov Today Technol. 2019. PMID: 33357765 Free article. Review. No abstract available.
3,806 results