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Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction.
Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W. Shao T, et al. Among authors: donde h. J Hepatol. 2018 Oct;69(4):886-895. doi: 10.1016/j.jhep.2018.05.021. Epub 2018 May 25. J Hepatol. 2018. PMID: 29803899 Free PMC article.
Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice.
Singhal R, Donde H, Ghare S, Stocke K, Zhang J, Vadhanam M, Reddy S, Gobejishvili L, Chilton P, Joshi-Barve S, Feng W, McClain C, Hoffman K, Petrosino J, Vital M, Barve S. Singhal R, et al. Among authors: donde h. Gut Microbes. 2021 Jan-Dec;13(1):1946367. doi: 10.1080/19490976.2021.1946367. Gut Microbes. 2021. PMID: 34369304 Free PMC article.
Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.
Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Myers SA, et al. Among authors: donde h. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. Neurobiol Dis. 2019. PMID: 30557659 Free PMC article.