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Page 1
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation.
Silva CMS, Wanderley CWS, Veras FP, Sonego F, Nascimento DC, Gonçalves AV, Martins TV, Cólon DF, Borges VF, Brauer VS, Damasceno LEA, Silva KP, Toller-Kawahisa JE, Batah SS, Souza ALJ, Monteiro VS, Oliveira AER, Donate PB, Zoppi D, Borges MC, Almeida F, Nakaya HI, Fabro AT, Cunha TM, Alves-Filho JC, Zamboni DS, Cunha FQ. Silva CMS, et al. Among authors: donate pb. Blood. 2021 Dec 23;138(25):2702-2713. doi: 10.1182/blood.2021011525. Blood. 2021. PMID: 34407544 Free PMC article.
Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity.
Nascimento DC, Viacava PR, Ferreira RG, Damaceno MA, Piñeros AR, Melo PH, Donate PB, Toller-Kawahisa JE, Zoppi D, Veras FP, Peres RS, Menezes-Silva L, Caetité D, Oliveira AER, Castro ÍMS, Kauffenstein G, Nakaya HI, Borges MC, Zamboni DS, Fonseca DM, Paschoal JAR, Cunha TM, Quesniaux V, Linden J, Cunha FQ, Ryffel B, Alves-Filho JC. Nascimento DC, et al. Among authors: donate pb. Immunity. 2021 Sep 14;54(9):2024-2041.e8. doi: 10.1016/j.immuni.2021.08.005. Epub 2021 Sep 1. Immunity. 2021. PMID: 34473957 Free article.
The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis.
Castanheira FVES, Borges V, Sônego F, Kanashiro A, Donate PB, Melo PH, Pallas K, Russo RC, Amaral FA, Teixeira MM, Ramalho FS, Cunha TM, Liew FY, Alves-Filho JC, Graham GJ, Cunha FQ. Castanheira FVES, et al. Among authors: donate pb. Shock. 2018 Jun;49(6):682-689. doi: 10.1097/SHK.0000000000000969. Shock. 2018. PMID: 29589840
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis.
Colón DF, Wanderley CW, Franchin M, Silva CM, Hiroki CH, Castanheira FVS, Donate PB, Lopes AH, Volpon LC, Kavaguti SK, Borges VF, Speck-Hernandez CA, Ramalho F, Carlotti AP, Carmona F, Alves-Filho JC, Liew FY, Cunha FQ. Colón DF, et al. Among authors: donate pb. Crit Care. 2019 Apr 8;23(1):113. doi: 10.1186/s13054-019-2407-8. Crit Care. 2019. PMID: 30961634 Free PMC article.
Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis.
Peres RS, Liew FY, Talbot J, Carregaro V, Oliveira RD, Almeida SL, França RF, Donate PB, Pinto LG, Ferreira FI, Costa DL, Demarque DP, Gouvea DR, Lopes NP, Queiroz RH, Silva JS, Figueiredo F, Alves-Filho JC, Cunha TM, Ferreira SH, Louzada-Junior P, Cunha FQ. Peres RS, et al. Among authors: donate pb. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2509-14. doi: 10.1073/pnas.1424792112. Epub 2015 Feb 9. Proc Natl Acad Sci U S A. 2015. PMID: 25675517 Free PMC article.
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
Peres RS, Donate PB, Talbot J, Cecilio NT, Lobo PR, Machado CC, Lima KWA, Oliveira RD, Carregaro V, Nakaya HI, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, Cunha FQ. Peres RS, et al. Among authors: donate pb. J Autoimmun. 2018 Jun;90:49-58. doi: 10.1016/j.jaut.2018.01.004. Epub 2018 Feb 14. J Autoimmun. 2018. PMID: 29426578
Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis.
Donate PB, Alves de Lima K, Peres RS, Almeida F, Fukada SY, Silva TA, Nascimento DC, Cecilio NT, Talbot J, Oliveira RD, Passos GA, Alves-Filho JC, Cunha TM, Louzada-Junior P, Liew FY, Cunha FQ. Donate PB, et al. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2017120118. doi: 10.1073/pnas.2017120118. Epub 2020 Dec 21. Proc Natl Acad Sci U S A. 2021. PMID: 33443169 Free PMC article.
26 results